dc.contributor.author
Mohr, Bettina
dc.contributor.author
Difrancesco, Stephanie
dc.contributor.author
Harrington, Karen
dc.contributor.author
Evans, Samuel
dc.date.accessioned
2018-06-08T03:32:55Z
dc.date.available
2014-12-12T14:37:22.267Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15406
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19594
dc.description.abstract
The role of the two hemispheres in the neurorehabilitation of language is
still under dispute. This study explored the changes in language-evoked brain
activation over a 2-week treatment interval with intensive constraint induced
aphasia therapy (CIAT), which is also called intensive language action therapy
(ILAT). Functional magnetic resonance imaging (fMRI) was used to assess brain
activation in perilesional left hemispheric and in homotopic right hemispheric
areas during passive listening to high and low-ambiguity sentences and non-
speech control stimuli in chronic non-fluent aphasia patients. All patients
demonstrated significant clinical improvements of language functions after
therapy. In an event-related fMRI experiment, a significant increase of BOLD
signal was manifest in right inferior frontal and temporal areas. This
activation increase was stronger for highly ambiguous sentences than for
unambiguous ones. These results suggest that the known language improvements
brought about by intensive constraint-induced language action therapy at least
in part relies on circuits within the right-hemispheric homologs of left-
perisylvian language areas, which are most strongly activated in the
processing of semantically complex language.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
dc.title
Changes of right-hemispheric activation after constraint-induced, intensive
language action therapy in chronic aphasia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Hum. Neurosci. - 8 (2014), Artikel Nr. 919
dc.title.subtitle
fMRI evidence from auditory semantic processing
dcterms.bibliographicCitation.doi
10.3389/fnhum.2014.00919
dcterms.bibliographicCitation.url
http://journal.frontiersin.org/journal/10.3389/fnhum.2014.00919/abstract
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021452
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004271
dcterms.accessRights.openaire
open access