dc.contributor.author
Zhang, Xuejiao
dc.contributor.author
Malhotra, Shashwat
dc.contributor.author
Molina, Maria
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2018-06-08T03:30:39Z
dc.date.available
2015-04-16T11:04:02.905Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15334
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19522
dc.description.abstract
Micro- or nanosized three-dimensional crosslinked polymeric networks have been
designed and described for various biomedical applications, including living
cell encapsulation, tissue engineering, and stimuli responsive controlled
delivery of bioactive molecules. For most of these applications, it is
necessary to disintegrate the artificial scaffold into nontoxic residues with
smaller dimensions to ensure renal clearance for better biocompatibility of
the functional materials. This can be achieved by introducing stimuli-
cleavable linkages into the scaffold structures. pH, enzyme, and redox
potential are the most frequently used biological stimuli. Moreover, some
external stimuli, for example light and additives, are also used to trigger
the disintegration of the carriers or their assembly. In this review, we
highlight the recent progress in various chemical and physical methods for
synthesizing and crosslinking micro- and nanogels, as well as their
development for incorporation of cleavable linkages into the network of micro-
and nanogels.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Micro- and nanogels with labile crosslinks – from synthesis to biomedical
applications
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Chemical Society Reviews. - 44 (2015), 7, S. 1948-1973
dcterms.bibliographicCitation.doi
10.1039/C4CS00341A
dcterms.bibliographicCitation.url
http://pubs.rsc.org/en/Content/ArticleLanding/2015/CS/C4CS00341A#!divAbstract
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.funding
OpenAccess Publikation in Allianzlizenz
refubium.mycore.fudocsId
FUDOCS_document_000000022205
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004771
dcterms.accessRights.openaire
open access