dc.contributor.author
Ruan, Haowen
dc.contributor.author
Jang, Mooseok
dc.contributor.author
Judkewitz, Benjamin
dc.contributor.author
Yang, Changhuei
dc.date.accessioned
2018-06-08T03:30:30Z
dc.date.available
2015-01-13T14:19:15.123Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15324
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19512
dc.description.abstract
The Time-Reversed Ultrasound-Encoded (TRUE) light technique enables
noninvasive focusing deep inside scattering media. However, the time-reversal
procedure usually has a low signal-to-noise ratio because the intensity of
ultrasound-encoded light is intrinsically low. Consequently, the contrast and
resolution of TRUE focus is far from ideal, especially in the backscattering
geometry, which is more practical in many biomedical applications. To improve
the light intensity and resolution of TRUE focus, we developed an iterative
TRUE (iTRUE) light focusing technique that employs the TRUE focus itself as a
signal source (rather than diffused light) for subsequent TRUE procedures.
Importantly, this iTRUE technique enables light focusing in backscattering
mode. Here, we demonstrate the concept by focusing light in between scattering
layers in a backscattering configuration and show that the light intensity at
the focus is progressively enhanced by a factor of ~20. By scanning across a
fluorescent bead between these two scattering layers, the focusing resolution
in the ultrasound axial and lateral directions was improved ~2-fold and
~3-fold, respectively. We further explored the application of iTRUE in
biological samples by focusing light between 1 mm thick chicken tissue and
cartilage, and light intensity enhancements of the same order were also
observed.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Iterative Time-Reversed Ultrasonically Encoded Light Focusing in
Backscattering Mode
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 4 (2014), Artikel Nr. 7156
dcterms.bibliographicCitation.doi
10.1038/srep07156
dcterms.bibliographicCitation.url
http://www.nature.com/srep/2014/141121/srep07156/full/srep07156.html
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021576
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004363
dcterms.accessRights.openaire
open access