dc.contributor.author
Mantel, Hendrik T. J.
dc.contributor.author
Westerkamp, Andrie C.
dc.contributor.author
Adam, Rene
dc.contributor.author
Bennet, William F.
dc.contributor.author
Seehofer, Daniel
dc.contributor.author
Settmacher, Utz
dc.contributor.author
Sanchez-Bueno, Francisco
dc.contributor.author
Prous, Joan Fabregat
dc.contributor.author
Boleslawski, Emmanuel
dc.contributor.author
Friman, Styrbjorn
dc.contributor.author
Porte, Robert J.
dc.date.accessioned
2018-06-08T03:28:01Z
dc.date.available
2016-07-13T10:15:10.093Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15245
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19433
dc.description.abstract
Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained
attention since the Mayo Clinic reported their favorable results with the use
of a neo-adjuvant chemoradiation protocol. However, debate remains whether the
success of the protocol should be attributed to the neo-adjuvant therapy or to
the strict selection criteria that are being applied. The aim of this study
was to investigate the value of patient selection alone on the outcome of
liver transplantation for hCCA. In this retrospective study, patients that
were transplanted for hCCA between1990 and 2010 in Europe were identified
using the European Liver Transplant Registry (ELTR). Twenty-one centers
reported 173 patients (69%) of a total of 249 patients in the ELTR. Twenty-six
patients were wrongly coded, resulting in a study group of 147 patients. We
identified 28 patients (19%) who met the strict selection criteria of the Mayo
Clinic protocol, but had not undergone neo-adjuvant chemoradiation therapy.
Five–year survival in this subgroup was 59%, which is comparable to patients
with pretreatment pathological confirmed hCCA that were transplanted after
completion of the chemoradiation protocol at the Mayo Clinic. In conclusion,
although the results should be cautiously interpreted, this study suggests
that with strict selection alone, improved survival after transplantation can
be achieved, approaching the Mayo Clinic experience.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::617 Chirurgie und verwandte medizinische Einrichtungen
dc.title
Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar
Cholangiocarcinoma Is Associated with Improved Survival
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 6, Artikel Nr. e0156127
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0156127
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0156127
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024995
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006768
dcterms.accessRights.openaire
open access