dc.contributor.author
Wenz, Benjamin
dc.contributor.author
Nielsen, Stine
dc.contributor.author
Gassowski, Martyna
dc.contributor.author
Santos-Hoevener, Claudia
dc.contributor.author
Cai, Wei
dc.contributor.author
Ross, R. Stefan
dc.contributor.author
Bock, Claus-Thomas
dc.contributor.author
Ratsch, Boris-Alexander
dc.contributor.author
Kuecherer, Claudia
dc.contributor.author
Bannert, Norbert
dc.contributor.author
Bremer, Viviane
dc.contributor.author
Hamouda, Osamah
dc.contributor.author
Marcus, Ulrich
dc.contributor.author
Zimmermann, Ruth
dc.date.accessioned
2018-06-08T03:27:26Z
dc.date.available
2016-10-04T10:33:13.210Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15207
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19395
dc.description.abstract
Background People who inject drugs (PWID) are at increased risk of acquiring
and transmitting HIV and Hepatitis C (HCV) due to sharing injection
paraphernalia and unprotected sex. To generate seroprevalence data on HIV and
HCV among PWID and related data on risk behaviour, a multicentre sero- and
behavioural survey using respondent driven sampling (RDS) was conducted in
eight German cities between 2011 and 2014. We also evaluated the feasibility
and effectiveness of RDS for recruiting PWID in the study cities. Methods
Eligible for participation were people who had injected drugs within the last
12 months, were 16 years or older, and who consumed in one of the study
cities. Participants were recruited, using low-threshold drop-in facilities as
study sites. Initial seeds were selected to represent various sub-groups of
people who inject drugs (PWID). Participants completed a face-to-face
interview with a structured questionnaire about socio-demographics, sexual and
injecting risk behaviours, as well as the utilisation of health services.
Capillary blood samples were collected as dried blood spots and were
anonymously tested for serological and molecular markers of HIV and HCV. The
results are shown as range of proportions (min. and max. values (%)) in the
respective study cities. For evaluation of the sampling method we applied
criteria from the STROBE guidelines. Results Overall, 2,077 PWID were
recruited. The range of age medians was 29–41 years, 18.5–35.3 % of
participants were female, and 9.2–30.6 % were foreign born. Median time span
since first injection were 10–18 years. Injecting during the last 30 days was
reported by 76.0–88.4 % of participants. Sharing needle/syringes (last 30
days) ranged between 4.7 and 22.3 %, while sharing unsterile paraphernalia
(spoon, filter, water, last 30 days) was reported by 33.0–43.8 %. A majority
of participants (72.8–85.8 %) reported incarceration at least once, and
17.8–39.8 % had injected while incarcerated. Between 30.8 and 66.2 % were
currently in opioid substitution therapy. Unweighted HIV seroprevalence ranged
from 0–9.1 %, HCV from 42.3–75.0 %, and HCV-RNA from 23.1–54.0 %. The
implementation of RDS as a recruiting method in cooperation with low-threshold
drop in facilities was well accepted by both staff and PWID. We reached our
targeted sample size in seven of eight cities. Conclusions In the recruited
sample of mostly current injectors with a long duration of injecting drug use,
seroprevalence for HIV and HCV varied greatly between the city samples. HCV
was endemic among participants in all city samples. Our results demonstrate
the necessity of intensified prevention strategies for blood-borne infections
among PWID in Germany.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Sero- and behavioural survey
dc.subject
Respondent-driven sampling
dc.subject
Second generation surveillance
dc.subject
Injecting drug users
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
High variability of HIV and HCV seroprevalence and risk behaviours among
people who inject drugs
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
BMC Public Health. - 16(2016), Artikel Nr. 927
dc.title.subtitle
results from a cross-sectional study using respondent-driven sampling in eight
German cities (2011–14)
dcterms.bibliographicCitation.doi
10.1186/s12889-016-3545-4
dcterms.bibliographicCitation.url
http://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-3545-4
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025473
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007163
dcterms.accessRights.openaire
open access