dc.contributor.author
Kelhälä, Hanna-Leena
dc.contributor.author
Palatsi, Riitta
dc.contributor.author
Fyhrquist, Nanna
dc.contributor.author
Lehtimäki, Sari
dc.contributor.author
Väyrynen, Juha P.
dc.contributor.author
Kallioinen, Matti
dc.contributor.author
Kubin, Minna E.
dc.contributor.author
Greco, Dario
dc.contributor.author
Tasanen, Kaisa
dc.contributor.author
Alenius, Harri
dc.contributor.author
Bertino, Beatrice
dc.contributor.author
Carlavan, Isabelle
dc.contributor.author
Mehul, Bruno
dc.contributor.author
Déret, Sophie
dc.contributor.author
Reiniche, Pascale
dc.contributor.author
Martel, Philippe
dc.contributor.author
Marty, Carine
dc.contributor.author
Blume-Peytavi, Ulrike
dc.contributor.author
Voegel, Johannes J.
dc.contributor.author
Lauerma, Antti
dc.date.accessioned
2018-06-08T03:27:00Z
dc.date.available
2014-09-26T07:02:38.743Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15199
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19387
dc.description.abstract
The mechanisms of inflammation in acne are currently subject of intense
investigation. This study focused on the activation of adaptive and innate
immunity in clinically early visible inflamed acne lesions and was performed
in two independent patient populations. Biopsies were collected from lesional
and non-lesional skin of acne patients. Using Affymetrix Genechips, we
observed significant elevation of the signature cytokines of the Th17 lineage
in acne lesions compared to non-lesional skin. The increased expression of
IL-17 was confirmed at the RNA and also protein level with real-time PCR (RT-
PCR) and Luminex technology. Cytokines involved in Th17 lineage
differentiation (IL-1β, IL-6, TGF-β, IL23p19) were remarkably induced at the
RNA level. In addition, proinflammatory cytokines and chemokines (TNF-α, IL-8,
CSF2 and CCL20), Th1 markers (IL12p40, CXCR3, T-bet, IFN-γ), T regulatory cell
markers (Foxp3, IL-10, TGF-β) and IL-17 related antimicrobial peptides
(S100A7, S100A9, lipocalin, hBD2, hBD3, hCAP18) were induced. Importantly,
immunohistochemistry revealed significantly increased numbers of IL-17A
positive T cells and CD83 dendritic cells in the acne lesions. In summary our
results demonstrate the presence of IL-17A positive T cells and the activation
of Th17-related cytokines in acne lesions, indicating that the Th17 pathway is
activated and may play a pivotal role in the disease process, possibly
offering new targets of therapy.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
IL-17/Th17 Pathway Is Activated in Acne Lesions
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 9 (2014), 8, Artikel Nr. e105238
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0105238
dcterms.bibliographicCitation.url
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0105238
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021033
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000003964
dcterms.accessRights.openaire
open access