dc.contributor.author
Herzog, Dominik
dc.contributor.author
Poellinger, Alexander
dc.contributor.author
Doellinger, Felix
dc.contributor.author
Schuermann, Dirk
dc.contributor.author
Temmesfeld-Wollbrueck, Bettina
dc.contributor.author
Froeling, Vera
dc.contributor.author
Schreiter, Nils F.
dc.contributor.author
Neumann, Konrad
dc.contributor.author
Hippenstiel, Stefan
dc.contributor.author
Suttorp, Norbert
dc.contributor.author
Hubner, Ralf-Harto
dc.date.accessioned
2018-06-08T03:21:56Z
dc.date.available
2015-06-29T12:36:31.270Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15006
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19194
dc.description.abstract
Objective Endoscopic lung volume reduction (ELVR) with valves has been shown
to improve COPD patients with severe emphysema. However, a major complication
is pneumothoraces, occurring typically soon after valve implantation, with
severe consequences if not managed promptly. Based on the knowledge that
strain activity is related to a higher risk of pneumothoraces, we asked
whether modifying post-operative medical care with the inclusion of strict
short-term limitation of strain activity is associated with a lower incidence
of pneumothorax. Methods Seventy-two (72) emphysematous patients without
collateral ventilation were treated with bronchial valves and included in the
study. Thirty-two (32) patients received standard post-implantation medical
management (Standard Medical Care (SMC)), and 40 patients received a modified
medical care that included an additional bed rest for 48 hours and cough
suppression, as needed (Modified Medical Care (MMC)). Results The baseline
characteristics were similar for the two groups, except there were more males
in the SMC cohort. Overall, ten pneumothoraces occurred up to four days after
ELVR, eight pneumothoraces in the SMC, and only two in the MMC cohorts
(p=0.02). Complicated pneumothoraces and pneumothoraces after upper lobe
treatment were significantly lower in MMC (p=0.02). Major clinical outcomes
showed no significant differences between the two cohorts. Conclusions In
conclusion, modifying post-operative medical care to include bed rest for 48
hours after ELVR and cough suppression, if needed, might reduce the incidence
of pneumothoraces. Prospective randomized studies with larger numbers of well-
matched patients are needed to confirm the data.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Modifying Post-Operative Medical Care after EBV Implant May Reduce
Pneumothorax Incidence
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 5, Artikel Nr. e0128097
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0128097
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128097
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022722
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005121
dcterms.accessRights.openaire
open access