dc.contributor.author
Ghadjar, Pirus
dc.contributor.author
Hayoz, Stefanie
dc.contributor.author
Zimmermann, Frank
dc.contributor.author
Bodis, Stephan
dc.contributor.author
Kaul, David
dc.contributor.author
Badakhshi, Harun
dc.contributor.author
Bernier, Jacques
dc.contributor.author
Studer, Gabriela
dc.contributor.author
Plasswilm, Ludwig
dc.contributor.author
Budach, Volker
dc.contributor.author
Aebersold, Daniel M.
dc.date.accessioned
2018-06-08T03:20:16Z
dc.date.available
2015-03-13T12:00:06.683Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14962
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19150
dc.description.abstract
Background To analyze the impact of weight loss before and during
chemoradiation on survival outcomes in patients with locally advanced head and
neck cancer. Methods From 07/1994-07/2000 a total of 224 patients with
squamous cell carcinoma of the head and neck were randomized to either
hyperfractionated radiation therapy alone or the same radiation therapy
combined with two cycles of concomitant cisplatin. The primary endpoint was
time to any treatment failure (TTF); secondary endpoints were locoregional
recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and
overall survival (OS). Patient weight was measured 6 months before treatment,
at treatment start and treatment end. Results The proportion of patients with
>5% weight loss was 32% before, and 51% during treatment, and the proportion
of patients with >10% weight loss was 12% before, and 17% during treatment.
After a median follow-up of 9.5 years (range, 0.1 – 15.4 years) weight loss
before treatment was associated with decreased TTF, LRRFS, DMFS, cancer
specific survival and OS in a multivariable analysis. However, weight loss
during treatment was not associated with survival outcomes. Conclusions Weight
loss before and during chemoradiation was commonly observed. Weight loss
before but not during treatment was associated with worse survival.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Impact of weight loss on survival after chemoradiation for locally advanced
head and neck Cancer
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Radiation Oncology. - 10 (2015), 1, Artikel Nr. 21
dc.title.subtitle
secondary results of a randomized phase III trial (SAKK 10/94)
dcterms.bibliographicCitation.doi
10.1186/s13014-014-0319-y
dcterms.bibliographicCitation.url
http://www.ro-journal.com/content/10/1/21
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022046
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004673
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1748-717X