dc.contributor.author
Philipsborn, Peter von
dc.contributor.author
Steinbeis, Fridolin
dc.contributor.author
Bender, Max E.
dc.contributor.author
Regmi, Sadie
dc.contributor.author
Tinnemann, Peter
dc.date.accessioned
2018-06-08T03:19:42Z
dc.date.available
2015-03-13T12:36:37.467Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14938
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19126
dc.description.abstract
Background: Economic growth in low- and middle-income countries (LMIC) has
raised interest in how disease burden patterns are related to economic
development. Meanwhile, poverty-related diseases are considered to be
neglected in terms of research and development (R&D;). Objectives:
Developing intuitive and meaningful metrics to measure how different diseases
are related to poverty and neglected in the current R&D; system. Design:
We measured how diseases are related to economic development with the income
relation factor (IRF), defined by the ratio of disability-adjusted life-years
(DALYs) per 100,000 inhabitants in LMIC versus that in high-income countries.
We calculated the IRF for 291 diseases and injuries and 67 risk factors
included in the Global Burden of Disease Study 2010. We measured neglect in
R&D; with the neglect factor (NF), defined by the ratio of disease burden
in DALYs (as percentage of the total global disease burden) and R&D;
expenditure (as percentage of total global health-related R&D;
expenditure) for 26 diseases. Results: The disease burden varies considerably
with the level of economic development, shown by the IRF (median: 1.38;
interquartile range (IQR): 0.79–6.3). Comparison of IRFs from 1990 to 2010
highlights general patterns of the global epidemiological transition. The 26
poverty-related diseases included in our analysis of neglect in R&D; are
responsible for 13.8% of the global disease burden, but receive only 1.34% of
global health-related R&D; expenditure. Within this group, the NF varies
considerably (median: 19; IQR: 6–52). Conclusions: The IRF is an intuitive and
meaningful metric to highlight shifts in global disease burden patterns. A
large shortfall exists in global R&D; spending for poverty-related and
neglected diseases, with strong variations between diseases.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Poverty-related and neglected diseases – an economic and epidemiological
analysis of poverty relatedness and neglect in research and development
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Glob Health Action. - 8 (2015), Artikel Nr. 25818
dcterms.bibliographicCitation.doi
10.3402/gha.v8.25818
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3402/gha.v8.25818
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022050
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004675
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1654-9880