dc.contributor.author
Malt, Eva A.
dc.contributor.author
Juhasz, Katalin
dc.contributor.author
Malt, Ulrik F.
dc.contributor.author
Naumann, Thomas
dc.date.accessioned
2018-06-08T03:17:24Z
dc.date.available
2016-04-28T10:20:43.459Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14860
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19049
dc.description.abstract
Schizophrenia is a highly heritable disorder with diverse mental and somatic
symptoms. The molecular mechanisms leading from genes to disease pathology in
schizophrenia remain largely unknown. Genome-wide association studies (GWASs)
have shown that common single-nucleotide polymorphisms associated with
specific diseases are enriched in the recognition sequences of transcription
factors that regulate physiological processes relevant to the disease. We have
used a “bottom-up” approach and tracked a developmental trajectory from
embryology to physiological processes and behavior and recognized that the
transcription factor NK2 homeobox 1 (NKX2-1) possesses properties of
particular interest for schizophrenia. NKX2-1 is selectively expressed from
prenatal development to adulthood in the brain, thyroid gland, parathyroid
gland, lungs, skin, and enteric ganglia, and has key functions at the
interface of the brain, the endocrine-, and the immune system. In the
developing brain, NKX2-1-expressing progenitor cells differentiate into
distinct subclasses of forebrain GABAergic and cholinergic neurons,
astrocytes, and oligodendrocytes. The transcription factor is highly expressed
in mature limbic circuits related to context-dependent goal-directed patterns
of behavior, social interaction and reproduction, fear responses, responses to
light, and other homeostatic processes. It is essential for development and
mature function of the thyroid gland and the respiratory system, and is
involved in calcium metabolism and immune responses. NKX2-1 interacts with a
number of genes identified as susceptibility genes for schizophrenia. We
suggest that NKX2-1 may lie at the core of several dose dependent pathways
that are dysregulated in schizophrenia. We correlate the symptoms seen in
schizophrenia with the temporal and spatial activities of NKX2-1 in order to
highlight promising future research areas.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
brain development
dc.subject
thyroid hormones
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
A Role for the Transcription Factor Nk2 Homeobox 1 in Schizophrenia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Behav. Neurosci. - 10 (2016), Artikel Nr.59
dc.title.subtitle
Convergent Evidence from Animal and Human Studies
dcterms.bibliographicCitation.doi
10.3389/fnbeh.2016.00059
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3389/fnbeh.2016.00059
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024445
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006347
dcterms.accessRights.openaire
open access