dc.contributor.author
Gessele, Nikodemus
dc.contributor.author
Garcia-Pino, Elisabet
dc.contributor.author
Omerbašić, Damir
dc.contributor.author
Park, Thomas J.
dc.contributor.author
Koch, Ursula
dc.date.accessioned
2018-06-08T03:16:48Z
dc.date.available
2016-04-19T10:31:30.482Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14841
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19030
dc.description.abstract
Naked mole-rats (Heterocephalus glaber) live in large eu-social, underground
colonies in narrow burrows and are exposed to a large repertoire of
communication signals but negligible binaural sound localization cues, such as
interaural time and intensity differences. We therefore asked whether monaural
and binaural auditory brainstem nuclei in the naked mole-rat are
differentially adjusted to this acoustic environment. Using antibody stainings
against excitatory and inhibitory presynaptic structures, namely the vesicular
glutamate transporter VGluT1 and the glycine transporter GlyT2 we identified
all major auditory brainstem nuclei except the superior paraolivary nucleus in
these animals. Naked mole-rats possess a well structured medial superior
olive, with a similar synaptic arrangement to interaural-time-difference
encoding animals. The neighboring lateral superior olive, which analyzes
interaural intensity differences, is large and elongated, whereas the medial
nucleus of the trapezoid body, which provides the contralateral inhibitory
input to these binaural nuclei, is reduced in size. In contrast, the cochlear
nucleus, the nuclei of the lateral lemniscus and the inferior colliculus are
not considerably different when compared to other rodent species. Most
interestingly, binaural auditory brainstem nuclei lack the membrane-bound
hyperpolarization-activated channel HCN1, a voltage-gated ion channel that
greatly contributes to the fast integration times in binaural nuclei of the
superior olivary complex in other species. This suggests substantially
lengthened membrane time constants and thus prolonged temporal integration of
inputs in binaural auditory brainstem neurons and might be linked to the
severely degenerated sound localization abilities in these animals.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Structural Changes and Lack of HCN1 Channels in the Binaural Auditory
Brainstem of the Naked Mole-Rat (Heterocephalus glaber)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 1, Artikel Nr. e0146428
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0146428
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146428
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000024028
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006299
dcterms.accessRights.openaire
open access