dc.contributor.author
Omerbasic, Damir
dc.contributor.author
Smith, Ewan St. J.
dc.contributor.author
Moroni, Mirko
dc.contributor.author
Homfeld, Johanna
dc.contributor.author
Eigenbrod, Ole
dc.contributor.author
Bennett, Nigel C.
dc.contributor.author
Reznick, Jane
dc.contributor.author
Faulkes, Chris G.
dc.contributor.author
Selbach, Matthias
dc.contributor.author
Lewin, Gary R.
dc.date.accessioned
2018-06-08T03:16:24Z
dc.date.available
2016-11-16T12:43:24.808Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14817
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19006
dc.description.abstract
The naked mole-rat is a subterranean rodent lacking several pain behaviors
found in humans, rats, and mice. For example, nerve growth factor (NGF), an
important mediator of pain sensitization, fails to produce thermal
hyperalgesia in naked mole-rats. The sensitization of capsaicin-sensitive
TRPV1 ion channels is necessary for NGF-induced hyperalgesia, but naked mole-
rats have fully functional TRPV1 channels. We show that exposing isolated
naked mole-rat nociceptors to NGF does not sensitize TRPV1. However, the naked
mole-rat NGF receptor TrkA displays a reduced ability to engage signal
transduction pathways that sensitize TRPV1. Between one- and three-amino-acid
substitutions in the kinase domain of the naked mole-rat TrkA are sufficient
to render the receptor hypofunctional, and this is associated with the absence
of heat hyperalgesia. Our data suggest that evolution has selected for a TrkA
variant that abolishes a robust nociceptive behavior in this species but is
still compatible with species fitness.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
nerve growth factor
dc.subject
transcriptome assembly
dc.subject
receptor kinase signaling
dc.subject
capsaicin receptor
dc.subject
electrophysiology
dc.subject
nociceptor development
dc.subject
calcium imaging
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the
African Naked Mole-Rat
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Cell Reports. - 17 (2016), 3, S. 748–758
dcterms.bibliographicCitation.doi
10.1016/j.celrep.2016.09.035
dcterms.bibliographicCitation.url
http://www.sciencedirect.com/science/article/pii/S2211124716312748
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025711
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007358
dcterms.accessRights.openaire
open access