dc.contributor.author
Meinzer, Marcus
dc.contributor.author
Lindenberg, Robert
dc.contributor.author
Sieg, Mira M.
dc.contributor.author
Nachtigall, Laura
dc.contributor.author
Ulm, Lena
dc.contributor.author
Flöel, Agnes
dc.date.accessioned
2018-06-08T03:13:29Z
dc.date.available
2014-10-09T13:15:44.719Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14711
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18901
dc.description.abstract
Language facilitation by transcranial direct current stimulation (tDCS) in
healthy individuals has generated hope that tDCS may also allow improving
language impairment after stroke (aphasia). However, current stimulation
protocols have yielded variable results and may require identification of
residual language cortex using functional magnetic resonance imaging (fMRI),
which complicates incorporation into clinical practice. Based on previous
behavioral studies that demonstrated improved language processing by motor
system pre-activation, the present study assessed whether tDCS administered to
the primary motor cortex (M1) can enhance language functions. This proof-of-
concept study employed a sham-tDCS controlled, cross-over, within-subject
design and assessed the impact of unilateral excitatory (anodal) and
bihemispheric (dual) tDCS in 18 healthy older adults during semantic word-
retrieval and motor speech tasks. Simultaneous fMRI scrutinized the neural
mechanisms underlying tDCS effects. Both active tDCS conditions significantly
improved word-retrieval compared to sham-tDCS. The direct comparison of
activity elicited by word-retrieval vs. motor-speech trials revealed bilateral
frontal activity increases during both anodal- and dual-tDCS compared to sham-
tDCS. This effect was driven by more pronounced deactivation of frontal
regions during the motor-speech task, while activity during word-retrieval
trials was unaffected by the stimulation. No effects were found in M1 and
secondary motor regions. Our results show that tDCS administered to M1 can
improve word-retrieval in healthy individuals, thereby providing a rationale
to explore whether M1-tDCS may offer a novel approach to improve language
functions in aphasia. Functional magnetic resonance imaging revealed neural
facilitation specifically during motor speech trials, which may have reduced
switching costs between the overlapping neural systems for lexical retrieval
and speech processing, thereby resulting in improved performance.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Transcranial direct current stimulation of the primary motor cortex improves
word-retrieval in older adults
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Frontiers in Aging Neuroscience. - 6 (2014), Artikel Nr. 253
dcterms.bibliographicCitation.doi
10.3389/fnagi.2014.00253
dcterms.bibliographicCitation.url
http://journal.frontiersin.org/journal/10.3389/fnagi.2014.00253/full
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021135
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004038
dcterms.accessRights.openaire
open access