dc.contributor.author
Langenkamp, Elise
dc.contributor.author
vom Hagen, Franziska M.
dc.contributor.author
Zwiers, Peter J.
dc.contributor.author
Moorlag, Henk E.
dc.contributor.author
Schouten, Jan P.
dc.contributor.author
Hammes, Hans-Peter
dc.contributor.author
Gouw, Annette S. H.
dc.contributor.author
Molema, Grietje
dc.date.accessioned
2018-06-08T03:10:23Z
dc.date.available
2014-03-05T18:54:12.871Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14622
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18814
dc.description.abstract
In established tumors, angiogenic endothelial cells (ECs) coexist next to
"quiescent" EC in matured vessels. We hypothesized that angio-gene expression
of B16.F10 melanoma would differ depending on the growth stage. Unraveling the
spatiotemporal nature thereof is essential for drug regimen design aimed to
affect multiple neovascularization stages. We determined the angiogenic
phenotype-represented by 52 angio-genes-and vascular morphology of small,
intermediate, and large s.c. growing mouse B16.F10 tumors and demonstrated
that expression of these genes did not differ between the different growth
stages. Yet vascular morphology changed dramatically from small vessels
without lumen in small to larger vessels with increased lumen size in
intermediate/large tumors. Separate analysis of these vascular morphologies
revealed a significant difference in αSMA expression in relation to vessel
morphology, while no relation with VEGF, HIF-1α, nor Dll4 expression levels
was observed. We conclude that the tumor vasculature remains actively engaged
in angiogenesis during B16.F10 melanoma outgrowth and that the major change in
tumor vascular morphology does not follow molecular concepts generated in
other angiogenesis models.
en
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16
Melanoma While Proangiogenic Gene Expression Remains Unchanged
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
ISRN Oncology, (2011), Artikel Nr. 409308/1-14
dcterms.bibliographicCitation.doi
10.5402/2011/409308
dcterms.bibliographicCitation.url
http://dx.doi.org/10.5402/2011/409308
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Klinik und Poliklinik für kleine Haustiere
refubium.mycore.fudocsId
FUDOCS_document_000000019791
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000003160
dcterms.accessRights.openaire
open access