dc.contributor.author
Skorska, Anna
dc.contributor.author
Haehling, Stephan von
dc.contributor.author
Ludwig, Marion
dc.contributor.author
Lux, Cornelia A.
dc.contributor.author
Gaebel, Ralf
dc.contributor.author
Kleiner, Gabriela
dc.contributor.author
Klopsch, Christian
dc.contributor.author
Dong, Jun
dc.contributor.author
Curato, Caterina
dc.contributor.author
Altarche-Xifró
dc.contributor.author
Slavic, Svetlana
dc.contributor.author
Unger, Thomas
dc.contributor.author
Steinhoff, Gustav
dc.contributor.author
Li, Jun
dc.contributor.author
David, Robert
dc.date.accessioned
2018-06-08T03:09:14Z
dc.date.available
2015-09-03T04:58:17.406Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14588
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18780
dc.description.abstract
Myocardial infarction (MI) is a major condition causing heart failure (HF).
After MI, the renin angiotensin system (RAS) and its signalling octapeptide
angiotensin II (Ang II) interferes with cardiac injury/repair via the AT1 and
AT2 receptors (AT1R, AT2R). Our study aimed at deciphering the mechanisms
underlying the link between RAS and cellular components of the immune response
relying on a rodent model of HF as well as HF patients. Flow cytometric
analyses showed an increase in the expression of CD4+ AT2R+ cells in the rat
heart and spleen post-infarction, but a reduction in the peripheral blood. The
latter was also observed in HF patients. The frequency of rat CD4+ AT2R+ T
cells in circulating blood, post-infarcted heart and spleen represented 3.8 ±
0.4%, 23.2 ± 2.7% and 22.6 ± 2.6% of the CD4+ cells. CD4+ AT2R+ T cells within
blood CD4+ T cells were reduced from 2.6 ± 0.2% in healthy controls to 1.7 ±
0.4% in patients. Moreover, we characterized CD4+ AT2R+ T cells which
expressed regulatory FoxP3, secreted interleukin-10 and other inflammatory-
related cytokines. Furthermore, intramyocardial injection of MI-induced
splenic CD4+ AT2R+ T cells into recipient rats with MI led to reduced infarct
size and improved cardiac performance. We defined CD4+ AT2R+ cells as a T cell
subset improving heart function post-MI corresponding with reduced infarction
size in a rat MI-model. Our results indicate CD4+ AT2R+ cells as a promising
population for regenerative therapy, via myocardial transplantation,
pharmacological AT2R activation or a combination thereof.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
angiotensin II type 2 receptor
dc.subject
renin angiotensin system
dc.subject
CD4 + lymphocytes
dc.subject
myocardial infarction
dc.subject
heart failure cardiac remodelling
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
The CD4+AT2R+T cell subpopulation improves post-infarction remodelling and
restores cardiac function
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Journal of Cellular and Molecular Medicine - 19 (2015), 8, S. 1975-1985
dcterms.bibliographicCitation.doi
10.1111/jcmm.12574
dcterms.bibliographicCitation.url
http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12574/abstract
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023043
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005357
dcterms.accessRights.openaire
open access