dc.contributor.author
Bozin, Ivan
dc.contributor.author
Ge, Yulin
dc.contributor.author
Kuchling, Joseph
dc.contributor.author
Dusek, Petr
dc.contributor.author
Chawla, Sanjeev
dc.contributor.author
Harms, Lutz
dc.contributor.author
Ruprecht, Klemens
dc.contributor.author
Niendorf, Thoralf
dc.contributor.author
Paul, Friedemann
dc.contributor.author
Kister, Ilya
dc.contributor.author
Sinnecker, Tim
dc.contributor.author
Wuerfel, Jens
dc.date.accessioned
2018-06-08T03:06:29Z
dc.date.available
2015-08-27T10:57:29.788Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14520
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18712
dc.description.abstract
Objective The analysis of the MR phase provides additional information on the
tissue microstructure. In multiple sclerosis (MS) lesions phase alterations
may reflect different stages of inflammatory activity. Here we investigated
lesion morphology in MS patients with short and long disease duration on T2*
weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7
Tesla (T). Methods 17 MS or clinically isolated syndrome patients with short
(<60 months) and 11 with long (>60 months) disease duration underwent 7T MRI.
Lesions were subsequently analyzed side-by-side with regard to morphology and
visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.
Results 126 of 192 T2* weighted lesions (65.6%) were characterized by a phase
alteration pattern, and hence could be differentiated on phase images. In
detail, a significantly reduced proportion of lesions showing phase
alterations was detectable in patients with longer disease duration (mean±SD
51±37%, range 0–100%) compared to patients with short disease duration
(mean±SD 90±19.5%, range 50–100%, p = 0.003). Conclusion This cross-sectional
study identified different patterns of phase changes in lesions of MS patients
with short and long standing disease. Longitudinal studies are warranted to
prove that MR phase imaging is useful in determining the activity and the
developmental stage of individual MS plaques.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short
and Long Disease Duration
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 7, Artikel Nr. e0128386
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0128386
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128386
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022984
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005317
dcterms.accessRights.openaire
open access