dc.contributor.author
Segata, Nicola
dc.contributor.author
Baldini, Francesco
dc.contributor.author
Pompon, Julien
dc.contributor.author
Garrett, Wendy S.
dc.contributor.author
Duy Tin Truong
dc.contributor.author
Dabire, Roch K.
dc.contributor.author
Diabate, Abdoulaye
dc.contributor.author
Levashina, Elena A.
dc.contributor.author
Catteruccia, Flaminia
dc.date.accessioned
2018-06-08T03:04:22Z
dc.date.available
2016-05-17T12:06:28.889Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14452
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18645
dc.description.abstract
Microbes play key roles in shaping the physiology of insects and can influence
behavior, reproduction and susceptibility to pathogens. In Sub-Saharan Africa,
two major malaria vectors, Anopheles gambiae and An. coluzzii, breed in
distinct larval habitats characterized by different microorganisms that might
affect their adult physiology and possibly Plasmodium transmission. We
analyzed the reproductive microbiomes of male and female An. gambiae and An.
coluzzii couples collected from natural mating swarms in Burkina Faso. 16S
rRNA sequencing on dissected tissues revealed that the reproductive tracts
harbor a complex microbiome characterized by a large core group of bacteria
shared by both species and all reproductive tissues. Interestingly, we
detected a significant enrichment of several gender-associated microbial
biomarkers in specific tissues, and surprisingly, similar classes of bacteria
in males captured from one mating swarm, suggesting that these males
originated from the same larval breeding site. Finally, we identified several
endosymbiotic bacteria, including Spiroplasma, which have the ability to
manipulate insect reproductive success. Our study provides a comprehensive
analysis of the reproductive microbiome of important human disease vectors,
and identifies a panel of core and endosymbiotic bacteria that can be
potentially exploited to interfere with the transmission of malaria parasites
by the Anopheles mosquito.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
The reproductive tracts of two malaria vectors are populated by a core
microbiome and by gender- and swarm-enriched microbial biomarkers
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 24207
dcterms.bibliographicCitation.doi
10.1038/srep24207
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep24207
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024556
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006423
dcterms.accessRights.openaire
open access