dc.contributor.author
Giuseppe, Romina di
dc.contributor.author
Kühn, Tilman
dc.contributor.author
Hirche, Frank
dc.contributor.author
Buijsse, Brian
dc.contributor.author
Dierkes, Jutta
dc.contributor.author
Fritsche, Andreas
dc.contributor.author
Kaaks, Rudolf
dc.contributor.author
Boeing, Heiner
dc.contributor.author
Stangl, Gabriele I.
dc.contributor.author
Weikert, Cornelia
dc.date.accessioned
2018-06-08T03:01:31Z
dc.date.available
2015-09-03T07:17:47.709Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14350
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18544
dc.description.abstract
Background Increased fibroblast growth factor 23 (FGF23), a bone-derived
hormone involved in the regulation of phosphate and vitamin D metabolism, has
been related to the development of cardiovascular disease (CVD) in chronic
kidney disease patients and in the general population. However, what
determines higher FGF23 levels is still unclear. Also, little is known about
the influence of diet on FGF23. The aim of this study was therefore to
identify demographic, clinical and dietary correlates of high FGF23
concentrations in the general population. Methods We performed a cross-
sectional analysis within a randomly selected subcohort of the European
Prospective Investigation into Cancer and Nutrition (EPIC)-Germany comprising
2134 middle-aged men and women. The Human FGF23 (C-Terminal) ELISA kit was
used to measure FGF23 in citrate plasma. Dietary data were obtained at
baseline via validated food frequency questionnaires including up to 148 food
items. Results Multivariable adjusted logistic regression showed that men had
a 66% lower and smokers a 64% higher probability of having higher FGF23 (≥ 90
RU/mL) levels compared, respectively, with women and nonsmokers. Each doubling
in parathyroid hormone, creatinine, and C-reactive protein was related to
higher FGF23. Among the dietary factors, each doubling in calcium and total
energy intake was related, respectively, to a 1.75 and to a 4.41 fold
increased probability of having higher FGF23. Finally, each doubling in the
intake of iron was related to an 82% lower probability of having higher FGF23
levels. Results did not substantially change after exclusion of participants
with lower kidney function. Conclusions In middle-aged men and women
traditional and non-traditional CVD risk factors were related to higher FGF23
concentrations. These findings may contribute to the understanding of the
potential mechanisms linking increased FGF23 to increased CVD risk.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Potential Predictors of Plasma Fibroblast Growth Factor 23 Concentrations
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 7, Artikel Nr. e0133580
dc.title.subtitle
Cross-Sectional Analysis in the EPIC-Germany Study
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0133580
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133580
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023048
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005360
dcterms.accessRights.openaire
open access