dc.contributor.author
Apostolova, Ivayla
dc.contributor.author
Rogasch, Julian
dc.contributor.author
Buchert, Ralph
dc.contributor.author
Wertzel, Heinz
dc.contributor.author
Achenbach, H. Jost
dc.contributor.author
Schreiber, Jens
dc.contributor.author
Riedel, Sandra
dc.contributor.author
Furth, Christian
dc.contributor.author
Lougovski, Alexandr
dc.contributor.author
Schramm, Georg
dc.contributor.author
Hofheinz, Frank
dc.contributor.author
Amthauer, Holger
dc.contributor.author
Steffen, Ingo G.
dc.date.accessioned
2018-06-08T03:00:17Z
dc.date.available
2015-01-12T08:00:37.217Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14298
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18493
dc.description.abstract
Background The aim of the present study was to evaluate the predictive value
of a novel quantitative measure for the spatial heterogeneity of FDG uptake,
the asphericity (ASP) in patients with non-small cell lung cancer (NSCLC).
Methods FDG-PET/CT had been performed in 60 patients (15 women, 45 men; median
age, 65.5 years) with newly diagnosed NSCLC prior to therapy. The FDG-PET
image of the primary tumor was segmented using the ROVER 3D segmentation tool
based on thresholding at the volume-reproducing intensity threshold after
subtraction of local background. ASP was defined as the relative deviation of
the tumor’s shape from a sphere. Univariate and multivariate Cox regression as
well as Kaplan-Meier (KM) analysis and log-rank test with respect to overall
(OAS) and progression-free survival (PFS) were performed for clinical
variables, SUVmax/mean, metabolically active tumor volume (MTV), total lesion
glycolysis (TLG), ASP and “solidity”, another measure of shape irregularity.
Results ASP, solidity and “primary surgical treatment” were significant
independent predictors of PFS in multivariate Cox regression with binarized
parameters (HR, 3.66; p < 0.001, HR, 2.11; p = 0.05 and HR, 2.09; p = 0.05),
ASP and “primary surgical treatment” of OAS (HR, 3.19; p = 0.02 and HR, 3.78;
p = 0.01, respectively). None of the other semi-quantitative PET parameters
showed significant predictive value with respect to OAS or PFS. Kaplan-Meier
analysis revealed a probability of 2-year PFS of 52% in patients with low ASP
compared to 12% in patients with high ASP (p < 0.001). Furthermore, it showed
a higher OAS rate in the case of low versus high ASP (1-year-OAS, 91% vs. 67%:
p = 0.02). Conclusions The novel parameter asphericity of pretherapeutic FDG
uptake seems to provide better prognostic value for PFS and OAS in NCSLC
compared to SUV, metabolic tumor volume, total lesion glycolysis and solidity.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Quantitative assessment of the asphericity of pretherapeutic FDG uptake as an
independent predictor of outcome in NSCLC
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
BMC Cancer. - 14 (2014), Artikel Nr. 896
dcterms.bibliographicCitation.doi
10.1186/1471-2407-14-896
dcterms.bibliographicCitation.url
http://www.biomedcentral.com/1471-2407/14/896
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021559
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004346
dcterms.accessRights.openaire
open access