dc.contributor.author
Wiers, C. E.
dc.contributor.author
Shumay, E.
dc.contributor.author
Volkow, N. D.
dc.contributor.author
Frieling, H.
dc.contributor.author
Kotsiari, A.
dc.contributor.author
Lindenmeyer, J.
dc.contributor.author
Walter, H.
dc.contributor.author
Bermpohl, F.
dc.date.accessioned
2018-06-08T02:56:43Z
dc.date.available
2016-02-04T13:01:03.785Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14185
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18382
dc.description.abstract
In alcohol-dependent (AD) patients, alcohol cues induce strong activations in
brain areas associated with alcohol craving and relapse, such as the nucleus
accumbens (NAc) and amygdala. However, little is known about the influence of
depressive symptoms, which are common in AD patients, on the brain’s
reactivity to alcohol cues. The methylation state of the dopamine transporter
gene (DAT) has been associated with alcohol dependence, craving and
depression, but its influence on neural alcohol cue reactivity has not been
tested. Here, we compared brain reactivity to alcohol cues in 38 AD patients
and 17 healthy controls (HCs) using functional magnetic resonance imaging and
assessed the influence of depressive symptoms and peripheral DAT methylation
in these responses. We show that alcoholics with low Beck’s Depression
Inventory scores (n=29) had higher cue-induced reactivity in NAc and amygdala
than those with mild/moderate depression scores (n=9), though subjective
perception of craving was higher in those with mild/moderate depression
scores. We corroborated a higher DAT methylation in AD patients than HCs, and
showed higher DAT methylation in AD patients with mild/moderate than low
depression scores. Within the AD cohort, higher methylation predicted craving
and, at trend level (P=0.095), relapse 1 year after abstinence. Finally, we
show that amygdala cue reactivity correlated with craving and DAT methylation
only in AD patients with low depression scores. These findings suggest that
depressive symptoms and DAT methylation are associated with alcohol craving
and associated brain processes in alcohol dependence, which may have important
consequences for treatment. Moreover, peripheral DAT methylation may be a
clinically relevant biomarker in AD patients.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Effects of depressive symptoms and peripheral DAT methylation on neural
reactivity to alcohol cues in alcoholism
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Translational Psychiatry. - 5 (2015) 9, Artikel Nr. e648
dcterms.bibliographicCitation.doi
10.1038/tp.2015.141
dcterms.bibliographicCitation.url
http://www.nature.com/tp/journal/v5/n9/full/tp2015141a.html
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023854
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005953
dcterms.accessRights.openaire
open access