dc.contributor.author
Bhatia, Sumati
dc.contributor.author
Dimde, Mathias
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2018-06-08T02:52:49Z
dc.date.available
2014-10-21T09:00:15.873Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14061
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18258
dc.description.abstract
Pathogens adhere to the host cells during the first steps of infection through
multivalent interactions which involve protein–glycan recognition. Multivalent
interactions are also involved at different stages of immune response.
Insights into these multivalent interactions generate a way to use suitable
carbohydrate ligands that are attached to a basic scaffold consisting of e.g.,
dendrimer, polymer, nanoparticle, etc., with a suitable linker. Thus a
multivalent architecture can be obtained with controllable spatial and
topology parameters which can interfere with pathogen adhesion. Multivalent
glycoconjugates bearing natural or unnatural carbohydrate antigen epitopes
have also been used as carbohydrate based vaccines to stimulate an innate and
adaptive immune response. Designing and synthesizing an efficient multivalent
architecture with optimal ligand density and a suitable linker is a
challenging task. This review presents a concise report on the endeavors to
potentially use multi- and polyvalent glycoconjugates as vaccines as well as
anti-infectious and anti-inflammatory drug candidates.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Multivalent glycoconjugates as vaccines and potential drug candidates
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
MedChemComm. - 5 (2014), 7, S. 862-878
dc.identifier.sepid
39607
dcterms.bibliographicCitation.doi
10.1039/C4MD00143E
dcterms.bibliographicCitation.url
http://xlink.rsc.org/?DOI=c4md00143e
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.funding
OpenAccess Publikation in Allianzlizenz
refubium.mycore.fudocsId
FUDOCS_document_000000021177
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004624
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
2040-2503