dc.contributor.author
Singec, Ilyas
dc.contributor.author
Knoth, Rolf
dc.contributor.author
Vida, Imre
dc.contributor.author
Frotscher, Michael
dc.date.accessioned
2018-06-08T02:52:35Z
dc.date.available
2015-12-17T12:50:45.244Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14052
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18249
dc.description.abstract
The mouse subventricular zone (SVZ) generates large numbers of neuroblasts,
which migrate in a distinct pathway, the rostral migratory stream (RMS), and
replace specific interneurons in the olfactory bulb (OB). Here, we introduce
an organotypic slice culture model that directly connects the RMS to the
hippocampus as a new destination. RMS neuroblasts widely populate the
hippocampus and undergo cellular differentiation. We demonstrate that RMS
cells give rise to various neuronal subtypes and, surprisingly, to CA1
pyramidal neurons. Pyramidal neurons are typically generated before birth and
are lost in various neurological disorders. Hence, this unique slice culture
model enables us to investigate their postnatal genesis under defined in vitro
conditions from the RMS, an unanticipated source for hippocampal pyramidal
neurons.
en
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons
in a novel organotypic slice co-culture model
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Biology Open. - 4 (2015), 10, S. 1222-1228
dcterms.bibliographicCitation.doi
10.1242/bio.012096
dcterms.bibliographicCitation.url
http://bio.biologists.org/content/4/10/1222
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023625
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005781
dcterms.accessRights.openaire
open access