dc.contributor.author
Barton, Ann Kristin
dc.contributor.author
Rieger, Martin
dc.contributor.author
Teschner, Dana
dc.contributor.author
Gehlen, Heidrun
dc.date.accessioned
2018-06-08T02:52:21Z
dc.date.available
2016-06-30T13:16:34.460Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14042
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18239
dc.description.abstract
Background: Procalcitonin, a precursor protein of the hormone calcitonin, is a
sensitive marker for sepsis in human medicine, which is used for diagnosis of
bacterial pneumonia in adults and neonates to initiate antibiotic therapy.
Objectives: In this study, procalcitonin was evaluated as a potential
biomarker for Rhodococcus equi associated pneumonia. Methods: In four foals
procalcitonin was measured at four time-points (day 0 before antibiotic
therapy, day 1, 3 and 5/6 during therapy) in plasma using an equine specific
ELISA. Inclusion criteria for the study were a positive sepsis score,
ultrasonographic evidence of pulmonary abscesses in addition >8 cm, a positive
microbiology out of tracheobronchial secretion and positive response to
antibiotic treatment (azithromycin 10 mg/kg BDW 24q PO and rifampicin 10 mg/kg
BDW 12q PO) within a weak including improvement of clinical status and
reduction of ultrasonographic score <8 cm. Results: Procalcitonin
concentrations remained below the working range of the ELISA (25 - 1000 ng/ml)
in all but one sample. Conclusions: Procalcitonin cannot be regarded a useful
biomarker in pneumonia associated with Rhodococcus equi.
en
dc.format.extent
7 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Rhodococcus equi
dc.subject.ddc
500 Naturwissenschaften und Mathematik
dc.title
Procalcitonin - A Useful Biomarker for Pneumonia Associated with Rhodococcus
equi?
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Modern Research in Inflammation, 2016, 5, S. 13-19
dcterms.bibliographicCitation.doi
10.4236/mri.2016.52002
dcterms.bibliographicCitation.url
http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=66351
refubium.affiliation
Veterinärmedizin
de
refubium.funding
Deutsche Forschungsgemeinschaft (DFG)
refubium.mycore.fudocsId
FUDOCS_document_000000024583
refubium.note.author
Gefördert durch die DFG und den Open-Access-Publikationsfonds der Freien
Universität Berlin
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006441
dcterms.accessRights.openaire
open access