Title:
Early diagnosis of septic arthritis and periprosthetic joint infections using new diagnostic methods in the synovial fluid
Subtitle:
Concept sheet for investigator-initiated trial (IIT), Version 1.0, January 17, 2020
Author(s):
Trampuz, Andrej; Karbysheva, Svetlana; Morovic, Paula; Koliszak, Anna; Johannsen, Lilith
Year of publication:
2025
Available Date:
2025-08-18T07:52:22Z
Abstract:
This is the original study protocol, created in 2020, for a prospective observational diagnostic study on synovial D-lactate in joint infections, conducted at Charité – Universitätsmedizin Berlin. The protocol forms the methodological foundation for two peer-reviewed publications already published and one additional article currently in preparation. It is made publicly available here to ensure transparency, enable reproducibility, and support adherence to STARD guidelines for diagnostic accuracy studies.
Keywords:
D-lactate
implant-associated infections
septic arthritis
biomarker
DDC-Classification:
618 Experimental medicine
Publication Type:
Sonstige Publikationen
Department/institution:
Charité - Universitätsmedizin Berlin
Comments:
The protocol was part of the ethics submission approved under EA1/026/20 and is directly related to the following peer-reviewed publications:
Karbysheva et al., 2024, Clinical Chemistry and Laboratory Medicine (DOI: 10.1515/cclm-2024-0556)
Fuchs et al., 2022, Frontiers in Surgery (DOI: 10.3389/fsurg.2022.1082591)
