dc.contributor.author
Al-Shebel, Amr
dc.contributor.author
Michel, Geert
dc.contributor.author
Breiderhoff, Tilman
dc.contributor.author
Müller, Dominik
dc.date.accessioned
2025-07-10T13:25:36Z
dc.date.available
2025-07-10T13:25:36Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/48202
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-47925
dc.description.abstract
Patients with mutations in Cldn16 suffer from familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) which can lead to renal insufficiency. Mice lacking claudin-16 show hypomagnesemia and hypercalciuria, but no nephrocalcinosis. Calcium oxalate and calcium phosphate are the most common insoluble calcium salts that accumulate in the kidney in the case of nephrocalcinosis, however, the formation of these salts is less favored in acidic conditions. Therefore, urine acidification has been suggested to limit the formation of calcium deposits in the kidney. Assuming that urine acidification is causative for the absence of nephrocalcinosis in the claudin-16-deficient mouse model, we aimed to alkalinize the urine of these mice by the ablation of the subunit B1 of the vesicular ATPase in addition to claudin-16. In spite of an increased urinary pH in mice lacking claudin-16 and the B1 subunit, nephrocalcinosis did not develop. Thus, urinary acidification is not the only factor preventing nephrocalcinosis in claudin-16 deficient mice.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC)
en
dc.subject
nephrocalcinosis
en
dc.subject
urinary acidification
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Urinary Acidification Does Not Explain the Absence of Nephrocalcinosis in a Mouse Model of Familial Hypomagnesaemia with Hypercalciuria and Nephrocalcinosis (FHHNC)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1779
dcterms.bibliographicCitation.doi
10.3390/ijms25031779
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
25
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
38339056
dcterms.isPartOf.eissn
1422-0067