dc.contributor.author
Neuhäusel, Tim Simon
dc.contributor.author
Gerevich, Zoltan
dc.date.accessioned
2025-07-09T14:23:22Z
dc.date.available
2025-07-09T14:23:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/48181
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-47903
dc.description.abstract
N-methyl-D-aspartate (NMDA) receptor antagonists are widely used to pharmacologically model schizophrenia and have been recently established in the treatment of treatment-resistant major depression demonstrating that the pharmacology of this substance class is complex. Cortical gamma oscillations, a rhythmic neuronal activity associated with cognitive processes, are increased in schizophrenia and deteriorated in depressive disorders and are increasingly used as biomarker in these neuropsychiatric diseases. The opposite use of NMDA receptor antagonists in schizophrenia and depression raises the question how their effects are in accordance with the observed disease pathophysiology and if these effects show a consequent sex-specificity. In this study in rats, we investigated the effects of subchronic (14 days) intraperitoneal injections of the NMDA receptor antagonist MK-801 at a subanesthetic daily dose of 0.2 mg/kg on the behavioral phenotype of adult female and male rats and on pharmacologically induced gamma oscillations measured ex vivo from the hippocampus. We found that MK-801 treatment leads to impaired recognition memory in the novel object recognition test, increased stereotypic behavior and reduced grooming, predominantly in female rats. MK-801 also increased the peak power of hippocampal gamma oscillations induced by kainate or acetylcholine only in female rats, without affecting the peak frequency of the oscillations. The findings indicate that blockade of NMDA receptors enhances gamma oscillations predominantly in female rats and this effect is associated with behavioral changes in females. The results are in accordance with clinical electrophysiological findings and highlight the importance of hippocampal gamma oscillations as a biomarker in schizophrenia and depression.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
electroencephalography (EEG)
en
dc.subject
gamma oscillations
en
dc.subject
sex-specific
en
dc.subject
electrophysiology
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Sex-specific effects of subchronic NMDA receptor antagonist MK-801 treatment on hippocampal gamma oscillations
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1425323
dcterms.bibliographicCitation.doi
10.3389/fnins.2024.1425323
dcterms.bibliographicCitation.journaltitle
Frontiers in Neuroscience
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
18
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
39170673
dcterms.isPartOf.eissn
1662-453X