dc.contributor.author
Römer, Claudia
dc.contributor.author
Czupajllo, Julia
dc.contributor.author
Wolfarth, Bernd
dc.contributor.author
Lerchbaumer, Markus H.
dc.contributor.author
Legerlotz, Kirsten
dc.date.accessioned
2024-12-19T13:33:36Z
dc.date.available
2024-12-19T13:33:36Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46034
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-45744
dc.description.abstract
Introduction: The musculoskeletal system (MSK) is one of the extragonadal target tissues of sex hormones: osteoblasts and osteocytes express estrogen receptors, while in fibroblasts of the anterior cruciate ligament (ACL) and myocytes of the vastus lateralis muscle (MVL), estrogen and progesterone receptors can be detected by immunoassay. Indeed, upon binding of sex hormones to the extragonadal receptors, the MSK seems to respond to varying levels of sex hormones with structural adaptation. Hormonal contraceptives can affect the musculoskeletal system; however, there is a lack of high-quality studies, and no recommendation for female athletes exists.
Material and Methods: This is a systematic review of publications on the effects of oral hormonal contraceptives on the biomechanical properties of tendons, muscles and ligaments, muscle strength, and soft tissue regeneration. A systematic database search was performed using MESH keywords and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology in Pubmed and Cochrane to identify studies investigating the influence of oral hormonal contraceptives on muscles, tendons, and ligaments of healthy, adult, premenopausal women. The risk of bias in the studies included was assessed by two independent researchers using the ROBINS-I Tool.
Results: Nine comparative studies were identified that met the inclusion criteria. Endpoints were muscle strength and biomechanical tissue properties. No significant influence of oral hormonal contraceptives on muscle strength was found, although general muscle growth and Type I fiber growth were found to be significantly increased in a dose-dependent manner. There was a negative effect on regeneration of muscle strength after exercise. The stiffness of tendons remained unchanged, while their size adaptation to load increased.
Conclusion: The anabolic effect could be beneficial for specific sports, whereas reduced muscle regeneration could be disadvantageous for women exercising with high-performance demands. The different effects on tendons and ligaments and the functional consequences of altered ligament and muscle stiffness, especially with regard to synthetic hormones, should be further investigated.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
oral hormonal contraceptives
en
dc.subject
premenopausal women
en
dc.subject
tendons and ligaments
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Effects of orally administered hormonal contraceptives on the musculoskeletal system of healthy premenopausal women—A systematic review
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e776
dcterms.bibliographicCitation.doi
10.1002/hsr2.776
dcterms.bibliographicCitation.journaltitle
Health Science Reports
dcterms.bibliographicCitation.number
5
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
5
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35957969
dcterms.isPartOf.eissn
2398-8835