dc.contributor.author
Wang, Youmeng
dc.contributor.author
Schoebel, Juliane
dc.contributor.author
Han, Jinming
dc.contributor.author
Kraemer, Jan F.
dc.contributor.author
Toncar, Theresa
dc.contributor.author
Siegert, Jacob
dc.contributor.author
Penzel, Thomas
dc.contributor.author
Schöbel, Christoph
dc.date.accessioned
2024-10-28T17:13:13Z
dc.date.available
2024-10-28T17:13:13Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/45425
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-45137
dc.description.abstract
Objective: Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF.
Methods: This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography.
Results: A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea-hypopnea index (41 +/- 18 vs 29 +/- 25, p = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% +/- 1% vs 95% +/- 2%, p = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea.
Conclusion: In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Heart failure
en
dc.subject
Central sleep apnea
en
dc.subject
Phrenic nerve stimulation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s11325-022-02699-8
dcterms.bibliographicCitation.journaltitle
Sleep and Breathing
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
1027
dcterms.bibliographicCitation.pageend
1032
dcterms.bibliographicCitation.volume
27
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35978055
dcterms.isPartOf.issn
1520-9512
dcterms.isPartOf.eissn
1522-1709
