dc.contributor.author
Amato-Lourenco, Luís Fernando
dc.contributor.author
Dantas, Katia Cristina
dc.contributor.author
Ribeiro Junior, Gabriel
dc.contributor.author
Paes, Vitor Ribeiro
dc.contributor.author
Ando, Rômulo Augusto
dc.contributor.author
de Oliveira Freitas, Raul
dc.contributor.author
da Costa, Ohanna Maria Menezes M.
dc.contributor.author
Rabelo, Renata S.
dc.contributor.author
Soares Bispo, Kelly Cristina
dc.contributor.author
Carvalho-Oliveira, Regiani
dc.date.accessioned
2024-10-15T13:23:43Z
dc.date.available
2024-10-15T13:23:43Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/45279
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44991
dc.description.abstract
Importance Microplastic (MP) pollution is an emerging environmental and health concern. While MPs have been detected in various human tissues, their presence in the human brain has not been documented, raising important questions about potential neurotoxic effects and the mechanisms by which MPs might reach brain tissues.
Objective To determine the presence of MPs in the human olfactory bulb and to analyze their characteristics such as size, morphology, color, and polymeric composition.
Design, Setting, and Participants This case series study used a cross-sectional design involving the analysis of olfactory bulb tissues obtained from deceased individuals during routine coroner autopsies. The sampling procedures were conducted at São Paulo City Death Verification Service, with laboratory analysis carried out at the Brazilian Synchrotron Light Laboratory (LNLS). Participants included 15 adult individuals who had been residents of São Paulo for more than 5 years and underwent coroner autopsies. Exclusion criteria included previous neurosurgical interventions. Data analysis was performed in April 2024.
Exposure The primary exposure assessed was the presence of MPs in the olfactory bulb, analyzed through direct tissue examination and digested tissue filtration followed by micro-Fourier transform infrared spectroscopy.
Main Outcomes and Measures The main outcomes were the identification and characterization of MPs within the olfactory bulb, including their size, morphology, color, and polymeric composition.
Results The median age of the 15 deceased individuals was 69.5 years, ranging from 33 to 100 years, with 12 males and 3 females. MPs were detected in the olfactory bulbs of 8 out of 15 individuals. A total of 16 synthetic polymer particles and fibers were identified, with 75% being particles and 25% being fibers. The most common polymer detected was polypropylene (43.8%). Sizes of MPs ranged from 5.5 μm to 26.4 μm for particles, and the mean fiber length was 21.4 μm. Polymeric materials were absent in procedural blank and negative control filters, indicating minimal contamination risk.
Conclusions and Relevance This case series provides evidence of MPs found in the human olfactory bulb, suggesting a potential pathway for the translocation of MPs to the brain. The findings underscore the need for further research on the health implications of MP exposure, particularly concerning neurotoxicity and the potential for MPs to bypass the blood-brain barrier.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Microplastics
en
dc.subject
Olfactory Bulb
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Microplastics in the Olfactory Bulb of the Human Brain
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e2440018
dcterms.bibliographicCitation.doi
10.1001/jamanetworkopen.2024.40018
dcterms.bibliographicCitation.journaltitle
JAMA Network Open
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.volume
7
dcterms.bibliographicCitation.url
https://doi.org/10.1001/jamanetworkopen.2024.40018
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Biologie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2574-3805
refubium.resourceType.provider
WoS-Alert