dc.contributor.author
Sroka, Dorota
dc.contributor.author
Lorenz-Meyer, Lisa-Antonia
dc.contributor.author
Scherfeld, Valerie
dc.contributor.author
Thoma, Julie
dc.contributor.author
Busjahn, Andreas
dc.contributor.author
Henrich, Wolfgang
dc.contributor.author
Verlohren, Stefan
dc.date.accessioned
2024-09-26T12:05:19Z
dc.date.available
2024-09-26T12:05:19Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/45038
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44749
dc.description.abstract
Introduction: The objective of this retrospective study was to compare the predictive performance of the soluble fms-like tyrosine kinase 1 (sFlt-1) / placental growth factor (PlGF)-ratio alone or in a multi-marker regression model for preeclampsia-related maternal and/or fetal adverse outcomes in women >34 weeks of gestation. Methods: We analyzed the data collected from 655 women with suspected preeclampsia. Adverse outcomes were predicted by multivariable and univariable logistic regression models. The outcome of patients was evaluated within 14 days after presentation with signs and symptoms of preeclampsia or diagnosed preeclampsia.Results: The full model integrating available, standard clinical information and the sFlt-1/PlGF-ratio had the best predictive performance for adverse outcomes with an AUC of 72.6%, which corresponds to a sensitivity of 73.3% and specificity of 66.0%. The positive predictive value of the full model was 51.4% and the negative predictive value was 83.5%. 24.5% of patients, who did not experience adverse outcomes but were classified as high risk by sFlt-1/PlGF-ratio (>= 38), were correctly classified by the regression model. The sFlt-1/PlGF-ratio alone had a significantly lower AUC of 65.6%.Conclusions: Integrating angiogenic biomarkers in a regression model improved the prediction of preeclampsia-related adverse outcomes in women at risk after 34 weeks of gestation.
en
dc.subject
Placenta Growth Factor
en
dc.subject
Pre-Eclampsia
en
dc.subject
Retrospective Studies
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Comparison of the Soluble fms-Like Tyrosine Kinase 1/Placental Growth Factor Ratio Alone versus a Multi-Marker Regression Model for the Prediction of Preeclampsia-Related Adverse Outcomes after 34 Weeks of Gestation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1159/000529781
dcterms.bibliographicCitation.journaltitle
Fetal Diagnosis and Therapy
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Karger
dcterms.bibliographicCitation.pagestart
215
dcterms.bibliographicCitation.pageend
224
dcterms.bibliographicCitation.volume
50
dcterms.rightsHolder.note
Copyright applies in this work.
dcterms.rightsHolder.url
http://rightsstatements.org/vocab/InC/1.0/
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
de
refubium.note.author
This publication is shared with permission of the rights owner and made freely accessible through a DFG (German Research Foundation) funded license at either an alliance or national level.
en
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36809755
dcterms.isPartOf.issn
1015-3837
dcterms.isPartOf.eissn
1421-9964