dc.contributor.author
Zaupa, Margherita
dc.contributor.author
Nagaraj, Nagarjuna
dc.contributor.author
Sylenko, Anna
dc.contributor.author
Baier, Herwig
dc.contributor.author
Sawamiphak, Suphansa
dc.contributor.author
Filosa, Alessandro
dc.date.accessioned
2024-08-13T13:13:24Z
dc.date.available
2024-08-13T13:13:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44532
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44244
dc.description.abstract
Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on the appropriate behavioral strategy by integrating external information from sensory organs and internal signals related to physiological needs. For example, a hungry animal may take more risks than a satiated one when deciding to approach or avoid an object. Using a proteomic profiling approach, we identified the Calmodulin-interacting peptide Pcp4a as a key regulator of foraging-related decisions. Food intake reduced abundance of protein and mRNA of pcp4a via dopamine D2-like receptor-mediated repression of adenylate cyclase. Accordingly, deleting the pcp4a gene made zebrafish larvae more risk averse in a binary decision assay. Strikingly, neurons in the tectum became less responsive to prey-like visual stimuli in pcp4a mutants, thus biasing the behavior toward avoidance. This study pinpoints a molecular mechanism modulating behavioral choice according to internal state.
en
dc.format.extent
22 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
decision-making
en
dc.subject
prey capture
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1016/j.neuron.2024.01.001
dcterms.bibliographicCitation.journaltitle
Neuron
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.pagestart
1150
dcterms.bibliographicCitation.pageend
1164.e6
dcterms.bibliographicCitation.volume
112
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.neuron.2024.01.001
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Biologie
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refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1097-4199
refubium.resourceType.provider
WoS-Alert