dc.contributor.author
Chillon, Thilo Samson
dc.contributor.author
Demircan, Kamil
dc.contributor.author
Hackler, Julian
dc.contributor.author
Heller, Raban A.
dc.contributor.author
Kaghazian, Peyman
dc.contributor.author
Moghaddam, Arash
dc.contributor.author
Schomburg, Lutz
dc.date.accessioned
2024-06-10T12:29:53Z
dc.date.available
2024-06-10T12:29:53Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/43804
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-43519
dc.description.abstract
The essential trace elements copper, selenium and zinc are of relevance for immunity and immune response to vaccination. In this longitudinal study, adult healthcare workers (n = 126) received two doses of an mRNA vaccine (BNT162b2), and longitudinal serum samples were prepared. Vaccine-induced antibodies and their neutralizing activity were analyzed, and the trace elements copper, zinc, and selenium along with the copper transporter ceruloplasmin were measured. Subjects with combined deficiency of copper and zinc, i.e. both in the lowest tertiles at baseline, displayed particularly low antibody titers at three (Double Q1: 13 AU/mL vs. not double Q1: 29 AU/mL) and six (Double Q1: 200 AU/mL vs. not double Q1: 425 AU/mL) weeks after vaccination (p < 0.05). The results indicate the potential importance of an adequate trace element status of copper and zinc for raising a strong vaccine-induced SARS-CoV-2 antibody response, and highlights the importance of considering combined micronutrient insufficiencies, as single deficiencies may synergize.
en
dc.subject
Trace elements
en
dc.subject
Ceruloplasmin
en
dc.subject
Micronutrients
en
dc.subject
Spurenelemente
de
dc.subject
Coeruloplasmin
de
dc.subject
Mikronährstoffe
de
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e20919
dcterms.bibliographicCitation.doi
10.1016/j.heliyon.2023.e20919
dcterms.bibliographicCitation.journaltitle
Heliyon
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.originalpublishername
Elsevier
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
37886755
dcterms.isPartOf.eissn
2405-8440