dc.contributor.author
Lin, Mei-Huei
dc.contributor.author
Kuo, Yan-Ting
dc.contributor.author
Danglad-Flores, José
dc.contributor.author
Sletten, Eric T.
dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2024-05-30T08:27:34Z
dc.date.available
2024-05-30T08:27:34Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/43536
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-43252
dc.description.abstract
The chemical synthesis of complex oligosaccharides relies on efficient and highly reproducible glycosylation reactions. The outcome of a glycosylation is contingent upon several environmental factors, such as temperature, acidity, the presence of residual moisture, as well as the steric, electronic, and conformational aspects of the reactants. Each glycosylation proceeds rapidly and with a high yield within a rather narrow temperature range. For better control over glycosylations and to ensure fast and reliable reactions, a systematic analysis of 18 glycosyl donors revealed the effect of reagent concentration, water content, protecting groups, and structure of the glycosyl donors on the activation temperature. With these insights, we parametrize the first step of the glycosylation reaction to be executed reliably and efficiently.
en
dc.format.extent
7 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Carbohydrates
en
dc.subject
Glycosylations
en
dc.subject
Thioglycoside
en
dc.subject
Protecting groups
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Parametric Analysis of Donor Activation for Glycosylation Reactions
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e202400479
dcterms.bibliographicCitation.doi
10.1002/chem.202400479
dcterms.bibliographicCitation.journaltitle
Chemistry - A European Journal
dcterms.bibliographicCitation.number
30
dcterms.bibliographicCitation.volume
30
dcterms.bibliographicCitation.url
https://doi.org/10.1002/chem.202400479
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1521-3765
refubium.resourceType.provider
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