dc.contributor.author
Langer, Henning T.
dc.contributor.author
West, Daniel
dc.contributor.author
Senden, Joan
dc.contributor.author
Spuler, Simone
dc.contributor.author
Loon, Luc J. C. van
dc.contributor.author
Baar, Keith
dc.date.accessioned
2024-03-05T12:31:46Z
dc.date.available
2024-03-05T12:31:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42646
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42370
dc.description.abstract
The molecular responses to acute resistance exercise are well characterized. However, how cellular signals change over time to modulate chronic adaptations to more prolonged exercise training is less well understood. We investigated anabolic signaling and muscle protein synthesis rates at several time points after acute and chronic eccentric loading. Adult rat tibialis anterior muscle was stimulated for six sets of ten repetitions, and the muscle was collected at 0 h, 6 h, 18 h and 48 h. In the last group of animals, 48 h after the first exercise bout a second bout was conducted, and the muscle was collected 6 h later (54 h total). In a second experiment, rats were exposed to four exercise sessions over the course of 2 weeks. Anabolic signaling increased robustly 6 h after the first bout returning to baseline between 18 and 48 h. Interestingly, 6 h after the second bout mTORC1 activity was significantly lower than following the first bout. In the chronically exercised rats, we found baseline anabolic signaling was decreased, whereas myofibrillar protein synthesis (MPS) was substantially increased, 48 h after the last bout of exercise. The increase in MPS occurred in the absence of changes to muscle fiber size or mass. In conclusion, we find that anabolic signaling is already diminished after the second bout of acute resistance type exercise. Further, chronic exposure to resistance type exercise training results in decreased basal anabolic signaling but increased overall MPS rates.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
skeletal muscle
en
dc.subject
chronically exercised
en
dc.subject
Myofibrillar protein synthesis rates
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
7553
dcterms.bibliographicCitation.doi
10.1038/s41598-022-11621-x
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35534615
dcterms.isPartOf.eissn
2045-2322