dc.contributor.author
Llano Sanchez, Karmele
dc.contributor.author
Baird, J. Kevin
dc.contributor.author
Nielsen, Aileen
dc.contributor.author
Nurillah, Andini
dc.contributor.author
Agustina, Fitria
dc.contributor.author
Komara
dc.contributor.author
Fadilah, Fina
dc.contributor.author
Prameswari, Wendi
dc.contributor.author
Nugraha, R. Taufiq P.
dc.contributor.author
Greenwood, Alex D.
dc.date.accessioned
2024-04-22T07:51:33Z
dc.date.available
2024-04-22T07:51:33Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42468
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42193
dc.description.abstract
Naturally acquired immunity to the different types of malaria in humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, Pongo pygmaeus, exposed to endemic Plasmodium pitheci malaria. A total of 2140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and polymerase chain reaction for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of >2000 parasites μL−1 blood but with no outward or clinical sign of illness were studied. Immature orangutans had higher-grade and more frequent parasitaemia events, but mature individuals were more likely to suffer from clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256 times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to P. pitheci illness among orangutans that wanes without re-exposure to the pathogen.
en
dc.format.extent
10 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
naturally acquired immunity
en
dc.subject
One Health-One Welfare
en
dc.subject
orangutan conservation
en
dc.subject
Plasmodium pitheci
en
dc.subject
veterinary parasitology
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Naturally Acquired Immunity to Plasmodium pitheci in Bornean Orangutans (Pongo pygmaeus)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1017/S0031182024000155
dcterms.bibliographicCitation.journaltitle
Parasitology
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.pagestart
380
dcterms.bibliographicCitation.pageend
389
dcterms.bibliographicCitation.volume
151
dcterms.bibliographicCitation.url
https://doi.org/10.1017/S0031182024000155
refubium.affiliation
Veterinärmedizin
refubium.funding
Cambridge
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1469-8161