dc.contributor.author
Ramesh, Niraja
dc.contributor.author
Escher, Marc
dc.contributor.author
Turrel, Oriane
dc.contributor.author
Lützkendorf, Janine
dc.contributor.author
Matkovic, Tanja
dc.contributor.author
Liu, Fan
dc.contributor.author
Sigrist, Stephan J.
dc.date.accessioned
2024-02-02T08:59:36Z
dc.date.available
2024-02-02T08:59:36Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42276
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42002
dc.description.abstract
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd-1, controls presynaptic long-term plasticity and the maintenance of olfactory memories in Drosophila. While Spn mutants could not trigger nanoscopic active zone remodeling under homeostatic challenge and failed to stably potentiate neurotransmitter release, concomitant reduction of Syd-1 rescued all these deficits. The Spn/Syd-1 antagonism converged on active zone close F-actin, and genetic or acute pharmacological depolymerization of F-actin rescued the Spn deficits by allowing access to synaptic vesicle release sites. Within the intrinsic mushroom body neurons, the Spn/Syd-1 antagonism specifically controlled olfactory memory stabilization but not initial learning. Thus, this evolutionarily conserved protein complex controls behaviorally relevant presynaptic long-term plasticity, also observed in the mammalian brain but still enigmatic concerning its molecular mechanisms and behavioral relevance.
en
dc.format.extent
28 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
neurotransmission
en
dc.subject
presynaptic plasticity
en
dc.subject
D. melanogaster
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e86084
dcterms.bibliographicCitation.doi
10.7554/eLife.86084
dcterms.bibliographicCitation.journaltitle
eLife
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.7554/eLife.86084
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Biologie
![Dieser Normdateneintrag wurde von einer Benutzerin oder einem Benutzer als gültig bestätigt.](/cache_202e45ad85b55efaeb29160f63cd3f3b/themes/FuCD/images/authority_control/invisible.gif)
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2050-084X
refubium.resourceType.provider
WoS-Alert