dc.contributor.author
Nelke, Christopher
dc.contributor.author
Kleefeld, Felix
dc.contributor.author
Preusse, Corinna
dc.contributor.author
Ruck, Tobias
dc.contributor.author
Stenzel, Werner
dc.date.accessioned
2023-11-03T16:28:28Z
dc.date.available
2023-11-03T16:28:28Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/41418
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-41140
dc.description.abstract
Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different sub-entities, with the exception perhaps being the presence or absence of the anti-cN-1A-antibody. In contrast to other IIM, IBM is characterized by a chronic and progressive disease course. Here, we discuss the pathophysiological framework of IBM and highlight the seemingly prototypical situations where IBM occurs in the context of other diseases. In this context, understanding common immune pathways might provide insight into the pathogenesis of IBM. Indeed, IBM is associated with a distinct set of conditions, such as human immunodeficiency virus (HIV) or hepatitis C-two conditions associated with premature immune cell exhaustion. Further, the pathomorphology of IBM is reminiscent of other muscle diseases, notably HIV-associated myositis or granulomatous myositis. Distinct immune pathways are likely to drive these commonalities and senescence of the CD8(+) T cell compartment is discussed as a possible mechanism of pathogenesis. Future effort directed at understanding the co-occurrence of IBM and associated diseases could prove valuable to better understand the enigmatic IBM pathophysiology.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Inclusion body myositis
en
dc.subject
Pathophysiology
en
dc.subject
Immune senescence
en
dc.subject
Cellular senescence
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Inclusion body myositis and associated diseases: an argument for shared immune pathologies
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
84
dcterms.bibliographicCitation.doi
10.1186/s40478-022-01389-6
dcterms.bibliographicCitation.journaltitle
Acta Neuropathologica Communications
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35659120
dcterms.isPartOf.eissn
2051-5960