dc.contributor.author
Fernández Vallone, Valeria
dc.contributor.author
Borzone, Francisco Raúl
dc.contributor.author
Martinez, Leandro Marcelo
dc.contributor.author
Giorello, María Belén
dc.contributor.author
Choi, Hosoon
dc.contributor.author
Dimase, Federico
dc.contributor.author
Feldman, Leonardo
dc.contributor.author
Bordenave, Raúl Horacio
dc.contributor.author
Chudzinski-Tavassi, Ana Marisa
dc.contributor.author
Batagelj, Emilio
dc.contributor.author
Chasseing, Norma Alejandra
dc.date.accessioned
2023-09-20T12:12:29Z
dc.date.available
2023-09-20T12:12:29Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40919
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40640
dc.description.abstract
Introduction: Osteolytic bone metastasis in advanced breast cancer stages are a major complication for patient ' s quality life and a sign of low survival prognosis. Permissive microenvironments which allow cancer cell secondary homing and later proliferation are fundamental for metastatic processes. The causes and mechanisms behind bone metastasis in breast cancer patients are still an unsolved puzzle. Therefore, in this work we contribute to describe bone marrow pre-metastatic niche in advanced breast cancer patients.
Results: We show an increase in osteoclasts precursors with a concomitant imbalance towards spontaneous osteoclastogenesis which can be evidenced at bone marrow and peripheral levels. Pro-osteoclastogenic factors RANKL and CCL-2 may contribute to bone resorption signature observed in bone marrow. Meanwhile, expression levels of specific microRNAs in primary breast tumors may already indicate a pro-osteoclastogenic scenario prior to bone metastasis.
Discussion: The discovery of prognostic biomarkers and novel therapeutic targets linked to bone metastasis initiation and development are a promising perspective for preventive treatments and metastasis management in advanced breast cancer patients.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
pre-metastatic niche
en
dc.subject
bone metastasis
en
dc.subject
spontaneous osteoclastogenesis
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1073793
dcterms.bibliographicCitation.doi
10.3389/fonc.2023.1073793
dcterms.bibliographicCitation.journaltitle
Frontiers in Oncology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
13
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36890825
dcterms.isPartOf.eissn
2234-943X