dc.contributor.author
Singh, Rajat Kumar
dc.date.accessioned
2023-08-08T12:08:47Z
dc.date.available
2023-08-08T12:08:47Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40246
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-39966
dc.description.abstract
Capsular polysaccharides (CPSs) on the surface of bacteria play an essential role in the virulence of bacteria by protecting them from the host's immune system. Because of their important role in bacterial virulence, CPSs are often targeted by vaccines and antimicrobial therapies. Carbohydrates-based vaccines can be developed to stimulate the immune system to produce antibodies against specific CPSs, which can then prevent or reduce the severity of infections caused by the targeted bacteria. The first part of the dissertation focused on synthesizing five novel synthetic oligosaccharides resembling the capsular polysaccharides of Streptococcus suis serotype 18 using solution-phase chemistry. The second part of the dissertation focused on the fungi Candida auris and describes the synthesis of oligosaccharides resembling the key immunogenic structure of Candida auris KCTC 17810.
en
dc.format.extent
ix, 124 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Carbohydrate
en
dc.subject
Carbohydrate-based vaccine
en
dc.subject
Streptococcus suis
en
dc.subject
Candida auris
en
dc.subject.ddc
500 Natural sciences and mathematics::540 Chemistry and allied sciences::547 Organic chemistry
dc.title
Chemical Synthesis of Oligosaccharides as Basis for the Development of Carbohydrate-Based Vaccine Candidates against Streptococcus suis Serotype 18 and Candida auris
dc.contributor.gender
male
dc.contributor.firstReferee
Seeberger, Peter
dc.contributor.furtherReferee
Koksch, Beate
dc.date.accepted
2023-07-20
dc.identifier.urn
urn:nbn:de:kobv:188-refubium-40246-8
refubium.affiliation
Biologie, Chemie, Pharmazie
dcterms.accessRights.dnb
free
dcterms.accessRights.openaire
open access
dcterms.accessRights.proquest
accept