Title:
COVID-19—from mucosal immunology to IBD patients
Author(s):
Weidinger, Carl; Hegazy, Ahmed Nabil; Glauben, Rainer; Siegmund, Britta
Year of publication:
2021
Available Date:
2023-06-20T12:48:58Z
Abstract:
Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
Part of Identifier:
ISSN (print): 1933-0219
e-ISSN (online): 1935-3456
Keywords:
COVID-19
Host-Pathogen Interactions
Inflammatory Bowel Diseases
Intestinal Mucosa
SARS-CoV-2
Severity of Illness Index
Symptom Assessment
Virus Internalization
DDC-Classification:
610 Medizin und Gesundheit
Publication Type:
Wissenschaftlicher Artikel
DOI of the Original Publication:
PubMed ID of the Original Publication:
Journaltitle:
Mucosal Immunology
Publisher:
Springer Nature
Department/institution:
Charité - Universitätsmedizin Berlin