The evaporation of volatile and moderately volatile elements from silicate glasses is an important topic in geosciences, environmental, and materials sciences. Glasses that contain volatile elements are used in a wide range of experimental studies, but the synthesis of volatile-bearing glasses at high temperatures as well as the choice of starting materials is challenging. Here, we present a new method for the synthesis of 15–20 g of moderately volatile- and volatile element-bearing boron-aluminosilicate glasses using a two-stage melting process. Results show that the glasses contain between 7000 and 10,000 μg/g Zn, Cu, or Te and ∼3000 μg/g S. In situ analyses with scanning electron microscopy and electron microprobe analysis confirm that all glasses are homogeneous for major and trace elements within the analytical uncertainties.