dc.contributor.author
Poller, Wolfgang
dc.contributor.author
Heidecker, Bettina
dc.contributor.author
Ammirati, Enrico
dc.contributor.author
Kuss, Andreas W.
dc.contributor.author
Tzvetkova, Ana
dc.contributor.author
Poller, Wolfram C.
dc.contributor.author
Skurk, Carsten
dc.contributor.author
Haghikia, Arash
dc.date.accessioned
2023-05-05T13:50:51Z
dc.date.available
2023-05-05T13:50:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/39273
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38991
dc.description.abstract
During the past few years, unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking advantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss the emerging clinical relevance of advanced diagnostics for cardiovascular diseases, including those associated with COVID-19-with a focus on the role of inflammation in cardiomyopathies and arrhythmias. Second, we consider newly identified immunological interactions at organ and system levels which affect cardiovascular pathogenesis. Thus, studies into immune influences arising from the intestinal system are moving towards therapeutic exploitation. Further, powerful new research tools have enabled novel insight into brain-immune system interactions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress-acting through defined brain regions-upon viral and cardiovascular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cardiovascular diseases
en
dc.subject
innate immunity
en
dc.subject
immunogenetics
en
dc.subject
noncoding genome
en
dc.subject
RNA interference
en
dc.subject
antisense therapeutics
en
dc.subject
gut microbiome
en
dc.subject
neuroimmunology
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Innate Immunity in Cardiovascular Diseases—Identification of Novel Molecular Players and Targets
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
335
dcterms.bibliographicCitation.doi
10.3390/jcm12010335
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36615135
dcterms.isPartOf.eissn
2077-0383