dc.contributor.author
Landsiedel, Robert
dc.contributor.author
Honarvar, Naveed
dc.contributor.author
Seiffert, Svenja Berit
dc.contributor.author
Oesch, Barbara
dc.contributor.author
Oesch, Franz
dc.date.accessioned
2023-04-20T13:05:09Z
dc.date.available
2023-04-20T13:05:09Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/39021
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38737
dc.description.abstract
Nanomaterials have outstanding and unprecedented advantageous material properties but may also cause adverse effects in humans upon exposure. Testing nanomaterials for genotoxic properties is challenging because traditional testing methods were designed for small, soluble molecules and may not be easily applicable without modifications. This review critically examines available genotoxicity tests for use with nanomaterials, including DNA damage tests such as the comet assay, gene mutation tests such as the mouse lymphoma and hprt assay, and chromosome mutation tests such as the micronucleus test and the chromosome aberration test. It presents arguments for the relative usefulness of various tests, such as preferring the micronucleus test over the chromosome aberration test for scoring chromosome mutations and preferring mammalian cell gene mutation tests because the Ames test has limited utility. Finally, it points out the open questions and further needs in adapting genotoxicity tests for nanomaterials, such as validation, reference nanomaterials, and the selection of top test concentrations, as well as the relevance and applicability of test systems and the need to define testing strategies.
This article is categorized under:
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine
en
dc.format.extent
35 Seiten
dc.rights
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
genotoxicity
en
dc.subject
mutagenicity
en
dc.subject
nanomaterials
en
dc.subject
test methods
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Genotoxicity testing of nanomaterials
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e1833
dcterms.bibliographicCitation.doi
10.1002/wnan.1833
dcterms.bibliographicCitation.journaltitle
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.volume
14
dcterms.bibliographicCitation.url
https://doi.org/10.1002/wnan.1833
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Pharmazie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1939-0041
refubium.resourceType.provider
DeepGreen