dc.contributor.author
Babina, Magda
dc.contributor.author
Franke, Kristin
dc.contributor.author
Bal, Gürkan
dc.date.accessioned
2023-03-28T10:54:59Z
dc.date.available
2023-03-28T10:54:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38613
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38329
dc.description.abstract
Mast cells are evolutionarily old cells and the principal effectors in allergic responses and inflammation. They are seeded from the yolk sac during embryogenesis or are derived from hematopoietic progenitors and are therefore related to other leukocyte subsets, even though they form a separate clade in the hematopoietic system. Herein, we systematically bundle information from several recent high-throughput endeavors, especially those comparing MCs with other cell types, and combine such information with knowledge on the genes' functions to reveal groups of neuronal markers specifically expressed by MCs. We focus on recent advances made regarding human tissue MCs, but also refer to studies in mice. In broad terms, genes hyper-expressed in MCs, but largely inactive in other myelocytes, can be classified into subcategories such as traffic/lysosomes (MLPH and RAB27B), the dopamine system (MAOB, DRD2, SLC6A3, and SLC18A2), Ca2+-related entities (CALB2), adhesion molecules (L1CAM and NTM) and, as an overall principle, the transcription factors and modulators of transcriptional activity (LMO4, PBX1, MEIS2, and EHMT2). Their function in MCs is generally unknown but may tentatively be deduced by comparison with other systems. MCs share functions with the nervous system, as they express typical neurotransmitters (histamine and serotonin) and a degranulation machinery that shares features with the neuronal apparatus at the synapse. Therefore, selective overlaps are plausible, and they further highlight the uniqueness of MCs within the myeloid system, as well as when compared with basophils. Apart from investigating their functional implications in MCs, a key question is whether their expression in the lineage is due to the specific reactivation of genes normally silenced in leukocytes or whether the genes are not switched off during mastocytic development from early progenitors.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
degranulation
en
dc.subject
adhesion molecules
en
dc.subject
solute carriers
en
dc.subject
transcription factors
en
dc.subject
monoamine oxidase B
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
How “Neuronal” Are Human Skin Mast Cells?
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
10871
dcterms.bibliographicCitation.doi
10.3390/ijms231810871
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
18
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
23
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36142795
dcterms.isPartOf.eissn
1422-0067