dc.contributor.author
Steffen, Claas Jasper
dc.contributor.author
Koch, Nadine
dc.contributor.author
Eckardt, Kai-Uwe
dc.contributor.author
Amann, K.
dc.contributor.author
Seelow, Evelyn
dc.contributor.author
Schreiber, Adrian
dc.date.accessioned
2023-03-15T14:26:09Z
dc.date.available
2023-03-15T14:26:09Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38400
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38118
dc.description.abstract
Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can occur in patients with underlying rheumatic or autoinflammatory disorders. Additionally, HLH can develop in patients during infections or malignancies without a known genetic predisposition.
Case presentation: We herein report a patient, who presented with fever, both acute kidney and liver injury, anemia, thrombocytopenia and HSV stomatitis. HLH was diagnosed based on clinical criteria and qPCR revealed an acute parvovirus B19 infection as potential underlying infectious trigger. Treatment was started with both IVIG and dexamethasone. Subsequently, kidney biopsy demonstrated TMA.
Conclusions: In rare cases both HLH and aHUS can occur simultaneously in a patient as a consequence of viral infections. Insights from this unusual case might help physicians understand this complex symptom constellation.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Hemophagocytic Lymphohistiocytosis (HLH)
en
dc.subject
Atypical hemorrhagic uremic syndrome (aHUS)
en
dc.subject
Parvovirus B19
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
337
dcterms.bibliographicCitation.doi
10.1186/s12882-021-02538-0
dcterms.bibliographicCitation.journaltitle
BMC Nephrology
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
22
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34641801
dcterms.isPartOf.eissn
1471-2369