dc.contributor.author
Winterer, Jeanne M.
dc.contributor.author
Ofosu, Kwaku
dc.contributor.author
Borchers, Friedrich
dc.contributor.author
Hadzidiakos, Daniel
dc.contributor.author
Lammers-Lietz, Florian
dc.contributor.author
Spies, Claudia
dc.contributor.author
Winterer, Georg
dc.contributor.author
Zacharias, Norman
dc.date.accessioned
2023-03-02T15:55:35Z
dc.date.available
2023-03-02T15:55:35Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38169
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37886
dc.description.abstract
Postoperative delirium (POD) represents a confusional state during days/weeks after surgery and is particularly frequent in elderly patients. Hardly any fMRI studies were conducted to understand the underlying pathophysiology of POD patients. This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3-5 months postoperatively) in delirious patients compared to no-POD patients. Two-hundred eighty-three elderly surgical patients underwent preoperative resting-state fMRI (46 POD). One-hundred seventy-eight patients completed postoperative scans (19 POD). For functional connectivity analyses, three functional connectivity networks with seeds located in the orbitofrontal cortex (OFC), nucleus accumbens (NAcc), and hippocampus were investigated. The relationship of POD and connectivity changes between both time points (course connectivity) were examined (ANOVA). Preoperatively, delirious patients displayed hyperconnectivities across the examined functional connectivity networks. In POD patients, connectivities within NAcc and OFC networks demonstrated a decrease in course connectivity [max. F = 9.03, p = 0.003; F = 4.47, p = 0.036, resp.]. The preoperative hyperconnectivity in the three networks in the patients at risk for developing POD could possibly indicate existing compensation mechanisms for subtle brain dysfunction. The observed pathophysiology of network function in POD patients at least partially involves dopaminergic pathways.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Postoperative delirium (POD)
en
dc.subject
Neurocognitive disorders
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
213
dcterms.bibliographicCitation.doi
10.1038/s41398-021-01304-y
dcterms.bibliographicCitation.journaltitle
Translational Psychiatry
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33846284
dcterms.isPartOf.eissn
2158-3188