dc.contributor.author
Urbański, Arkadiusz
dc.contributor.author
Johnston, Paul
dc.contributor.author
Bittermann, Elisa
dc.contributor.author
Keshavarz, Maryam
dc.contributor.author
Paris, Véronique
dc.contributor.author
Walkowiak-Nowicka, Karolina
dc.contributor.author
Konopińska, Natalia
dc.contributor.author
Marciniak, Paweł
dc.contributor.author
Rolff, Jens
dc.date.accessioned
2023-01-17T10:24:14Z
dc.date.available
2023-01-17T10:24:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37643
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37358
dc.description.abstract
Tachykinins (TKs) are a group of conserved neuropeptides. In insects, tachykinin-related peptides (TRPs) are important modulators of several functions such as nociception and lipid metabolism. Recently, it has become clear that TRPs also play a role in regulating the insect immune system. Here, we report a transcriptomic analysis of changes in the expression levels of immune-related genes in the storage pest Tenebrio molitor after treatment with Tenmo-TRP-7. We tested two concentrations (10–8 and 10–6 M) at two time points, 6 and 24 h post-injection. We found significant changes in the transcript levels of a wide spectrum of immune-related genes. Some changes were observed 6 h after the injection of Tenmo-TRP-7, especially in relation to its putative anti-apoptotic action. Interestingly, 24 h after the injection of 10–8 M Tenmo-TRP-7, most changes were related to the regulation of the cellular response. Applying 10–6 M Tenmo-TRP-7 resulted in the downregulation of genes associated with humoral responses. Injecting Tenmo-TRP-7 did not affect beetle survival but led to a reduction in haemolymph lysozyme-like antibacterial activity, consistent with the transcriptomic data. The results confirmed the immunomodulatory role of TRP and shed new light on the functional homology between TRPs and TKs.
en
dc.format.extent
19 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Antimicrobial responses
en
dc.subject
Environmental economics
en
dc.subject
Environmental social sciences
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
17277
dcterms.bibliographicCitation.doi
10.1038/s41598-022-21605-6
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41598-022-21605-6
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Biologie
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refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2045-2322
refubium.resourceType.provider
WoS-Alert