dc.contributor.author
Stoeckle, Sabita Diana
dc.contributor.author
Timmermann, Detlef
dc.contributor.author
Merle, Roswitha
dc.contributor.author
Gehlen, Heidrun
dc.date.accessioned
2023-01-05T15:27:05Z
dc.date.available
2023-01-05T15:27:05Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37474
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37187
dc.description.abstract
Pituitary pars intermedia dysfunction is one of the most common diseases of aged horses and ponies. In Parkinson’s disease, which is, similar to PPID, a disease that involves oxidative damage to dopaminergic pathways but with different clinical signs, alterations to the serum amino acid profile have been reported. To examine changes in the plasma amino acid profile in horses with PPID, EDTA plasma of horses that were presented for various reasons that required laboratory examinations of blood anticoagulated with EDTA was collected. With this plasma, the basal ACTH concentration as well as the amino acid profile was determined. Horses were considered PPID patients if the ACTH concentration was ≥ 100 pg/mL, i.e., they would be considered affected at any time. Horses were defined as non-PPID (nPPID) patients if the ACTH concentration was below 30 pg/mL. Horses receiving pergolide with ACTH ≤ 30 pg/mL were allocated to the group PPIDrr (PPID, ACTH in reference range) and horses receiving pergolide with ACTH ≥ 100 pg/mL to the group PPIDarr (PPID, ACTH above reference range). In total, 93 horses were examined, including 88 horses at the clinic and 5 horses at a private practice. Of these, 53 horses fulfilled the inclusion criteria (ACTH ≤ 30 pg/mL or ACTH ≥ 100 pg/mL). A total of 25 horses were diagnosed as nPPID, 20 as PPID, 5 as PPIDrr, and 3 as PPIDarr. Arginine was significantly higher in PPIDrr than in PPID and nPPID, asparagine was significantly higher in PPID, PPIDrr, and PPIDarr than in nPPID, citrulline was significantly higher in PPIDrr than in nPPID and PPID, cysteine was significantly lower in PPIDrr than in PPID, nPPID, and PPIDarr, and glutamine was significantly higher in PPID and PPIDarr than in nPPID. Especially, asparagine, citrulline, and glutamine may be potential diagnostic markers and may offer interesting approaches for research regarding amino supplementation in PPID.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
plasma amino acids
en
dc.subject
endocrine disease
en
dc.subject.ddc
600 Technology, Medicine, Applied sciences::630 Agriculture, Veterinary medicine::630 Agriculture, Veterinary medicine
dc.title
Plasma Amino Acids in Horses Suffering from Pituitary Pars Intermedia Dysfunction
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
3315
dcterms.bibliographicCitation.doi
10.3390/ani12233315
dcterms.bibliographicCitation.journaltitle
Animals
dcterms.bibliographicCitation.number
23
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.3390/ani12233315
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Veterinär-Epidemiologie und Biometrie
refubium.affiliation.other
Klinik für Pferde
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
de
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
2076-2615