dc.contributor.author
Singh, Abhishek Kumar
dc.contributor.author
Schade, Boris
dc.contributor.author
Rosati, Marta
dc.contributor.author
Rashmi, Rashmi
dc.contributor.author
Dichiarante, Valentina
dc.contributor.author
Cavallo, Gabriella
dc.contributor.author
Metrangolo, Pierangelo
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2022-11-29T12:31:27Z
dc.date.available
2022-11-29T12:31:27Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37082
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36796
dc.description.abstract
Amphiphiles containing fluorinated segments tend to aggregate in the aqueous solution into structure of lower curvature than their hydrocarbon analogs due to their larger diameter. A benefit of supramolecular structures incorporating fluorine moieties is their high electron density, which can be viewed in cryo‐TEM with better contrast than their hydrogenated forms. A modular approach has been developed for the synthesis of a new family of nonionic branched amphiphiles consisting of oligoglycerol units (G2) as the hydrophilic part and a branched fluorinated (F27) hydrophobic part. The design of this hydrophobic moiety allows to achieve a higher fluorine density than the previously used straight‐chain perfluoroalkanes. Two different chemical approaches, amide, and triazole, are used to link the hydrophilic and hydrophobic segments. In addition, the aggregation behavior is investigated by dynamic light scattering (DLS) and cryo‐TEM. The measurements prove the formation of multivesicular (MVVs) and multilamellar (MLVs) vesicles as well as smaller unilamellar vesicles. Further, the cell viability test proves the low cell toxicity of these nanoarchitectures for potential biomedical applications.
en
dc.format.extent
7 Seiten
dc.rights
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
dendritic amphiphile
en
dc.subject
perfluorinated tails
en
dc.subject
self‐assembly
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Synthesis and Linker‐Controlled Self‐Assembly of Dendritic Amphiphiles with Branched Fluorinated Tails
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2200108
dcterms.bibliographicCitation.doi
10.1002/mabi.202200108
dcterms.bibliographicCitation.journaltitle
Macromolecular Bioscience
dcterms.bibliographicCitation.number
11
dcterms.bibliographicCitation.volume
22
dcterms.bibliographicCitation.url
https://doi.org/10.1002/mabi.202200108
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
refubium.resourceType.provider
DeepGreen