dc.contributor.author
Ulas, Sevtap Tugce
dc.contributor.author
Hermann, Kay Geert
dc.contributor.author
Makowski, Marcus R.
dc.contributor.author
Biesen, Robert
dc.contributor.author
Proft, Fabian
dc.contributor.author
Schilling, Ralph
dc.contributor.author
Diekhoff, Torsten
dc.date.accessioned
2022-09-21T09:27:58Z
dc.date.available
2022-09-21T09:27:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36402
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36118
dc.description.abstract
Objective: To evaluate the performance of dynamic contrast-enhanced CT (DCE-CT) in detecting and quantitatively assessing perfusion parameters in patients with arthritis of the hand compared with dynamic contrast-enhanced MRI (DCE-MRI) as a standard of reference.
Materials and methods: In this IRB-approved randomized prospective single-centre study, 36 consecutive patients with suspected rheumatoid arthritis underwent DCE-CT (320-row, tube voltage 80 kVp, tube current 8.25 mAs) and DCE-MRI (1.5 T) of the hand. Perfusion maps were calculated separately for mean transit time (MTT), time to peak (TTP), relative blood volume (rBV), and relative blood flow (rBF) using four different decomposition techniques. Region of interest (ROI) analysis was performed in metacarpophalangeal joints II–V and in the wrist. Pairs of perfusion parameters in DCE-CT and DCE-MRI were compared using a two-tailed t test for paired samples and interpreted for effect size (Cohen’s d). According to the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) scoring results, differentiation of synovitis-positive and synovitis-negative joints with both modalities was assessed with the independent t test.
Results: The two modalities yielded similar perfusion parameters. Identified differences had small effects (d 0.01–0.4). DCE-CT additionally differentiates inflamed and noninflamed joints based on rBF and rBV but tends to underestimate these parameters in severe inflammation. The total dose-length product (DLP) was 48 mGy*cm with an estimated effective dose of 0.038 mSv.
Conclusion: DCE-CT is a promising imaging technique in arthritis. In patients with a contraindication to MRI or when MRI is not available, DCE-CT is a suitable alternative to detect and assess arthritis.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Computed tomography
en
dc.subject
Magnetic resonance imaging
en
dc.subject
Perfusion imaging
en
dc.subject
Arthritis, rheumatoid
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Perfusion in hand arthritis on dynamic contrast-enhanced computed tomography: a randomized prospective study using MRI as a standard of reference
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00256-020-03526-5
dcterms.bibliographicCitation.journaltitle
Skeletal Radiology
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
59
dcterms.bibliographicCitation.pageend
68
dcterms.bibliographicCitation.volume
50
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32607803
dcterms.isPartOf.issn
0364-2348
dcterms.isPartOf.eissn
1432-2161